Adipogen/Gitoxin/AG-CN2-0485-M025/25 mg
来自 :
发布时间：2024-05-09
More Information Product Details
Synonyms | Anhydrogitalin; Bigitalin; Pseudodigitoxin; NSC 95099; BRN0077015 |
Product Type | Chemical |
Properties
Formula | C41H64O14 |
MW | 780.9 |
CAS | 4562-36-1 |
RTECS | LZ0525000 |
Source/Host Chemicals | Isolated from Digitalis purpurea L. |
Purity Chemicals | ≥95% (NMR) |
Appearance | White powder. |
Solubility | Soluble in pyridine or DMSO. Sparingly soluble in 100% ethanol or methanol. Insoluble in water. |
Identity | Determined by 1H-NMR. |
InChi Key | LKRDZKPBAOKJBT-CNPIRKNPSA-N |
Shipping and Handling
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Keep cool and dry.Protect from light and moisture. |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents
MSDS ![](\"https://www.ebiomall.com/images/adipogen/download.png\") Download PDF |
Product Specification Sheet
Datasheet | Download PDF |
- Cardiac glycoside. Natural metabolite of digitoxin. Starting material for the synthesis of gitoxin derivatives with activity as cardiac glycosides.
- Uncompetitive inhibitor of the Na+/K+ ATPase activity.
- Inhibits growth of selected human cancer cells.
Product References
Studies on digitalis glycosides. VII. Gitoroside, digitalonin, and gitoxin pentaacetate: D. Satoh, et al.; Pharm. Bull. 5, 253 (1957)Effects of digoxin and gitoxin on the enzymatic activity and kinetic parameters of Na+/K+-ATPase: D. Krstic, et al.; J. Enzyme Inhib. Med. Chem. 19, 409 (2004)Na+/K+-ATPase: Activity and inhibition: M. Colovic, et al.; Russ. J. Phys. Chem. A. 83, 1602 (2009)A structural view on the functional importance of the sugar moiety and steroid hydroxyls of cardiotonic steroids in binding to Na,K-ATPase: F. Cornelius, et al.; J. Biol. Chem. 288, 6602 (2013)Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase: L. Moreno Y. Banuls, et al.; Mol. Cancer 12, 33 (2013)本文链接： http://adipogen.immuno-online.com/view-1458021355.html
