More Information Product Details
Synonyms | GS-4997 (free base); 5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-methylbenzamide |
Product Type | Chemical |
Properties
Formula | C24H24FN7O |
MW | 445.5 |
CAS | 1448428-04-3 |
Purity Chemicals | ≥95% |
Appearance | Solid. |
Solubility | Soluble in DMSO. Insoluble in water. |
Declaration | Manufactured by SynKinase. |
Other Product Data | Target: ASK1 | Kinase Group: Ser⁄Thr Kinases | Click here for Original Manufacturer Product DatasheetOur product description may differ slightly from the original manufacturers product datasheet. |
InChi Key | YIDDLAAKOYYGJG-UHFFFAOYSA-N |
Shipping and Handling
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Keep cool and dry. |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents
MSDS | No |
Product Specification Sheet
Datasheet ![](\"https://www.ebiomall.com/images/adipogen/download.png\") Download PDF |
Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.Product References
Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease: J.H. Lin, et al.; Nephron 129, 29 (2015)A Quantitative Framework to Evaluate Proarrhythmic Risk in a First-in-Human Study to Support Waiver of a Thorough QT Study: C.H. Nelson, et al.; Clin. Pharmacol. Ther. 98, 630 (2015)
