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Adipogen/RAP80 (UIM domains) (human) (rec.) (Biotin)/AG-40T-0349B-C250/250 µg
Adipogen/RAP80 (UIM domains) (human) (rec.) (Biotin)/AG-40T-0349B-C250/250 µg
商品编号：
AG-40T-0349B-C250
品牌：
Adipogen Inc
市场价：
¥7960.00
美元价：
4776.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ReceptorAssociatedProtein80;RXRIP110;UIMC1;X2HRIP110;BRCA1-AComplexSubunitRAP80;RetinoidXReceptor-interactingProtein110;UbiquitinInteractionMotif-containingProtein1 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanRAP80(UIMdomainsaa79-124)(AccessionNr.NP_057374)conjugatedtobiotin. |
| Crossreactivity | Human |
| Label/Conjugates | Biotin |
| Formulation | Liquid.In50mMHEPES,250mMNaCl,1mMDTT,5%GlycerolpH8.0. |
| OtherProductData | Use:Use50-100µgofproteintodetect10-20µgofpurifiedK63-linkedubiquitinchains.Theamountnecessaryforuseincrudelysatesneedstobedeterminedempirically.Detectionwithavidin-linkedreagentsallowsforahigherefficiencyanddetectionsensitivitythanwithotherantibodies. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Rap80(ReceptorAssociatedProtein80)interactswithBRCA1,aubiquitinE3-ligasewhichfunctionsinconjugationwiththeBARD1deubiquitinatingenzyme.BRCA1isrecruitedtoDNAdamagesitesbypoly-ubiquitinchainsthroughRap80whichcontains2tandemubiquitin-interactingmotifs(UIMs).Rap80constitutesaproteincomplexwithABRA1whichinteractswiththeBRCTdomainofBRCA1.UponDNAdamagetheRap80-ABRA1complextargetstheBRCA1-BARD1complextoK6-andK63-linkedpoly-ubiquitinchainsatthesefoci.TheUIMdomainsofRap80havebeenshowntohavepreferentialbindingtoK-6andK63-linkedubiquitinchainsandbindstoK48-chainwithamuchlowerefficiency.ItisnotknownifRap80UIMsinteractwithubiquitinchainslinkedviaK11,K27orK33.Rap80hasalowaffinityformono-,di-andtri-ubiquitinbutbindsefficientlytotetra(orgreater)ubiquitinchains.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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