脂肪原/谷丙烯醇A/AG-CR1-2903-M005/5毫克
商品编号：
AG-CR1-2903-M005
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
临床研究
公司分类：
clinical_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine;NG60 |
| ProductType | Chemical |
| Properties | |
| Formula | C19H25ClN6O |
| MW | 388.9 |
| CAS | 212844-53-6 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Off-whitepowder. |
| Solubility | SolubleinDMSO(30mg/ml),ethanol(10mg/ml),DMF(50mg/ml),methanolordichloromethane. |
| Identity | Determinedby1H-NMR. |
| InChiKey | PMXCMJLOPOFPBT-HNNXBMFYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potent,cellpermeablecyclin-dependentproteinkinase(cdk)inhibitor.InhibitshumanCDK1(IC50=4nM),CDK2/cyclinA(IC50=70nM),Cdc2/cyclinB,CDK2/cyclinE(IC50=35nM),CDK4/cyclinD1(IC50=850nM)aswellasCDK5/p35(IC50=75nM).
- DYRK1Ainhibitor(IC50=300nM).
- Anticanceragent.StrongapoptoticandautophagyinducerwhichcausescellcyclearrestintheG1andG2phaseinvariouscancercelllines.
- MoremembranepermeablethanpurvalanolB.
- ShowntoinhibitABCB1andABCB2transportersandusefulinco-treatmentwithselectedanticancerdrugs.
ProductReferences
- Exploitingchemicallibraries,structure,andgenomicsinthesearchforkinaseinhibitors:N.S.Gray,etal.;Science281,533(1998)
- Thespecificitiesofproteinkinaseinhibitors:Anupdate:J.Bain,etal.;Biochem.J.371,199(2003)
- CellulareffectsofpurvalanolA:Aspecificinhibitorofcyclin-dependentkinaseactivities:N.Villerbu,etal.;Int.J.Cancer97,761(2002)
- PurvalanolAinducesapoptosisanddownregulationofantiapoptoticproteinsthroughabrogationofphosphorylationofJAK2/STAT3andRNApolymeraseII:D.Iizuka,etal.;AnticancerDrugs19,565(2008)
- PurvalanolA,aCDKinhibitor,effectivelysuppressesSrc-mediatedtransformationbyinhibitingbothCDKsandc-Src:T.Hikita,etal.;GenestoCells15,1051(2010)
- OlomoucineIIandpurvalanolAinhibitABCG2transporterinvitroandinsituandsynergisticallypotentiatecytostaticeffectofmitoxantrone:J.Hofman,etal.;Pharmacol.Res.65,312(2012)
- PurvalanolA,olomoucineIIandroscovitineinhibitABCB1transporterandsynergisticallypotentiatecytotoxiceffectsofdaunorubicininvitro:D.Cihalova,etal.;PLoSOne8,e83467(2013)
- Purvalanolinducesendoplasmicreticulumstress-mediatedapoptosisandautophagyinatime-dependentmannerinHCT116coloncancercells:A.Coker-Gurkan,etal.;Oncol.Rep.33,2761(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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