脂肪原/丙酰-L-肉碱。盐酸盐/AG-CR1-3595-M100/100 mg
商品编号：
AG-CR1-3595-M100
品牌：
Adipogen Inc
市场价：
¥2600.00
美元价：
1560.00
产品分类：
临床研究
公司分类：
clinical_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | PLC |
| ProductType | Chemical |
| Properties | |
| Formula | C10H19NO4.HCl |
| MW | 217.3.36.5 |
| CAS | 119793-66-7 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | Solubleinwater,methanol,ethanol,DMSOordimethylformamide. |
| InChiKey | KTFMPDDJYRFWQE-DDWIOCJRSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Hygroscopic. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Naturallyoccurringcarnitinederivativeformedbycarnitineacetyltransferaseduringβ-oxidationofunevenchainfattyacids,withhighaffinityformuscularcarnitinetransferase.Increasescellularcarnitinecontent,allowingfreefattyacidtransportintothemitochondria[1,5].
- Stimulatesenergyproductioninischaemicmusclesbyincreasingcitricacidcyclefluxandstimulatingpyruvatedehydrogenaseactivity[1,2].
- Importantformitochondrialmetabolismandenergyregulation.Regulatesthemetabolismofbothcarbohydratesandlipids,leADIngtoanincreaseofATPgeneration[9,11].
- Selectivelyinhibitsinvitroandexvivoplatelet-activatingfactor(PAF)synthesisfromhumanneutrophils[3].
- Antioxidant.Showsfreeradicalscavengingactivity[4].
- DecreasestheexpressionofinducIBLenitricoxidesynthase(iNOS/NOSII)andNADPH-oxidase4-mediatedreactiveoxygenspeciesproductioninhumanumbilicalvascularendothelialcells[7].
- Showsbeneficialcardiovasculareffects.Improvesbodyweight,foodintake,adiposityandinsulinresistanceinType2diabetes[5,6,8-10].
- Stimulatesendothelialnitricoxide(eNOS/NOSIII)andincreasedNOproduction,viaAMPK/Src-mediatedsignalingthatleadstoactivationofPI3kinaseandAkt[6,12].
ProductReferences
- Changesinskeletalmusclehistologyandmetabolisminpatientsundergoingexercisedeconditioning:effectofpropionyl-L-carnitine:G.Brevetti,etal.;MuscleNerve20,1115(1997)
- Propionyl-L-carnitine:L.R.Wiseman&R.N.Brogden;DrugsAging12,243(1998)(Review)
- Inhibitionofplatelet-activatingfactorsynthesisinhumanneutrophilsandplateletsbypropionyl-L-carnitine:M.Triggiani,etal.;Biochem.Pharmacol.58,1341(1999)
- L-propionyl-carnitineassuperoxidescavenger,antioxidant,andDNAcleavageprotector:A.Vanella,etal.;CellBiol.Toxicol.16,99(2000)
- TherapeuticeffectsofL-carnitineandpropionyl-L-carnitineoncardiovasculardiseases:areview:R.Ferrari,etal.;Ann.N.Y.Acad.Sci.1033,79(2004)(Review)
- Oralsupplementationofpropionyl-l-carnitinereducesbodyweightandhyperinsulinaemiainobeseZuckerrats:C.Mingorance,etal.;Br.J.Nutr.102,1145(2009)
- Propionyl-L-carnitineimprovespostischemicbloodflowrecoveryandarteriogeneticrevascularizationandreducesendothelialNADPH-oxidase4-mediatedsuperoxideproduction:M.A.Stasi,etal.;Arterioscler.Thromb.Vasc.Biol.30,426(2010)
- CriticalupdatefortheclinicaluseofL-carnitineanalogsincardiometabolicdisorders:C.Mingorance,etal.;Vasc.HealthRiskManag.7,169(2011)
- Pharmacologicaleffectsandclinicalapplicationsofpropionyl-L-carnitine:C.Mingorance,etal.;Nutr.Rev.69,279(2011)(Review)
- Propionyl-L-carnitinecorrectsmetabolicandcardiovascularalterationsindiet-inducedobesemiceandimprovesliverrespiratorychainactivity:C.Mingorance,etal.;PLoSOne7,e34268(2012)
- Translatingthebasicknowledgeofmitochondrialfunctionstometabolictherapy:roleofL-carnitine:S.M.Marcovina,etal.;Transl.Res.161,73(2013)
- Propionyl-L-carnitineinduceseNOSactivationandnitricoxidesynthesisinendothelialcellsviaPI3andAktkinases:W.H.Ning&K.Zhao;Vascul.Pharmacol.59,76(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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