Adipogen/proTAME Solution/AG-CS1-0100-M001/1 mg
商品编号：
AG-CS1-0100-M001
品牌：
Adipogen Inc
市场价：
¥6980.00
美元价：
4188.00
产品分类：
临床研究
公司分类：
clinical_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | pro-Tosyl-L-ArginineMethylEster |
| ProductType | Chemical |
| Properties | |
| Formula | C34H38N4O12S |
| MW | 726.8 |
| CAS | 1362911-19-0 |
| PurityChemicals | ≥90% |
| Formulation | 20mMstocksolutioninDMSO. |
| Declaration | ManufacturedbyBostonBiochem |
| OtherProductData | Use:WhendilutingproTAMEintothecellgrowthmedium,itisbesttoaddtheDMSOstocksolutiontoanemptytubefirst,andthenaddalargevolumeofgrowthmediumfollowedbyimmediatemixing.proTAMEissparinglysolubleinaqueoussolutions.Toavoidprecipitation,instantandhighlyeffectivemixingisnecessary.Optimaldoseforeachcelllineneedstobeestablishedempiricallyduetocell-linespecificdifferencesinprodrugactivation.HeLaandhTERT-RPE1cellsactivatetheprodrugefficiently,withmitoticarrestobservedat12µMcompound.MCF10acellsactivatetheprodrugmuchlessefficiently. |
| InChiKey | MHYOVHULCQSDRZ-NDEPHWFRSA-N |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. Stocksolutionsarestableforatleast3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- CellpermeableprodrugcapableofinducingmitoticarrestandcelldeathinHeLaandothercelltypes.
- Inhibitoroftheubiquitinligaseactivityoftheanaphase-promotingcomplex/cyclosome(APC/C)bypreventingitsactivationbyCdc20andCdh1.
- proTAMEisconvertedtoitsactiveparentmolecule(TAME;Tosyl-L-argininemethylester)byintracellularesterases.
ProductReferences
- Pharmacologicinhibitionoftheanaphase-promotingcomplexinducesaspindlecheckpoint-dependentmitoticarrestintheabsenceofspindledamage:X.Zeng,etal.;CancerCell18,382(2010)
- CohesionfatigueexplainswhypharmacologicalinhibitionoftheAPC/Cinducesaspindlecheckpoint-dependentmitoticarrest:P.Lara-Gonzalez&S.S.Taylor;PLoSOne7,e49041(2012)
- TargetingmitoticexitwithhyperthermiaorAPC/Cinhibitiontoincreasepaclitaxelefficacy:S.Giovinazzi,etal.;CellCycle12,2598(2013)
- Targetingtheanaphase-promotingcomplex/cyclosome(APC/C)-bromodomaincontaining7(BRD7)pathwayforhumanosteosarcoma:K.Hu,etal.;Oncotarget5,3088(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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