脂肪原/Zmp1（M。肺结核）（记录）（His）/AG-40T-0103-C050/50µg
商品编号：
AG-40T-0103-C050
品牌：
Adipogen Inc
市场价：
¥7800.00
美元价：
4680.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ZincMetalloprotease1;Endopeptidase;Rv0198c |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | Full-lengthZmp1(Mycobacteriumtuberculosis)isfusedattheN-terminustoaHis-tag. |
| Specificity | PreferedcleavagesequenceisPxxF. |
| BIOLOGicalActivity | ~0.5U/mgprotein.ActivetowardsthegenericfluorogenicsubstrateformatrixmetalloproteinasesMMP2/MMP7(Lit.1). |
| MW | ~73.9kDa |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | N/A |
| Concentration | 0.5mg/ml(Lotspecific) |
| Formulation | Liquid.In10mMTRIS-HCl,pH8.0. |
| OtherProductData | UniProtlinkO53649:Zmp1(M.tuberculosis) |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-80°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
M13endopeptidasesaresingle-pass,transmembranezinc-metallopeptidasesresponsIBLeinhumanfortheregulationofthebiologicalactivityofmanyhormonesandpeptidesandareinvolvedinmanyimportantprocessessuchasbloodpressureregulation(NeprilysinorNEP1),cardiovasculardevelopment(EndothelinConvertingEnzyme-1orECE-12),preventionofhaemolyticreaction(KELL)andphosphatehomeostasis(PHEX).Zmp1isasolubleenzymememberoftheM13endopeptidasesfamilythatplaysakeyroleinMycobacteriumtuberculosispathogenicitywithastillunknownmechanism.Recently,itwasshowntosuppressinflammasomeactivationbyinhibitingcaspase-1activation,thuspreventingprocessingofpro-IL-1βintoIL-1βandtheconsequentphagosomematuration.
ProductReferences
- CrystalStructureofMycobacteriumtuberculosisZinc-dependentMetalloprotease-1(Zmp1),aMetalloproteaseInvolvedinPathogenicity:D.M.Ferraris,etal.;J.Biol.Chem.286,32475(2011)
- FunctionalcharacterizationoftheMycobacteriumtuberculosiszincmetallopeptidaseZmp1andidentificationofpotentialsubstrates:A.Petrera,etal.;J.Biol.Chem.393,631(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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