脂肪原/USP8（人类）（记录）（His）/AG-40T-0544-C025/25µg
商品编号：
AG-40T-0544-C025
品牌：
Adipogen Inc
市场价：
¥11020.00
美元价：
6612.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | UbiquitinC-terminalHydrolase8;DeubiquitinatingEnzyme8;UbiquitinIsopeptidaseY;UbiquitinThioesterase8;Ubiquitin-specific-processingProtease8;UBPY |
| ProductType | Protein |
| Properties | |
| Source/Host | Sf9cells |
| Sequence | HumanUSP8(AccessionNr.P40818)fusedtoaN-terminalHis-tag. |
| Crossreactivity | Human |
| Formulation | Liquid.InHEPES,NaCl,DTTandGlycerol. |
| OtherProductData | Use:Ubiquitin-specificdeconjugatingenzyme.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof10-50nM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
UbiquitinSpecificPeptidase8(USP8),alsoknownasubiquitinisopeptidaseY(UBPY),isawidelyexpresseddeubiquitinatingenzymebelongingtothepeptidaseC19family.Ithasapredictedmolecularweightof127.5kDa.HumanUSP8is1118aminoacids(aa)inlengthandshares84%aasequenceidentitywiththemouseandratorthologs.ItcontainsaN-terminalMITdomain(aa33-116)thatmediatesendosomallocalization,CHMP-binding,andmaintenanceofESCRT-0.USP8alsohasarhodanesedomain(aa181-319)thatbindsNRDP1ubiquitinligase(E3),aSH3domainbindingsequence(aa405-413),andaC-terminalcatalyticdomain(aa734-1110).USP8isagrowth-regulatedenzymethatcontrolstheinternalizationandendocytictraffickingofcellsurfacereceptors.Somereceptorsaretargetedforinternalizationanddegradationbyubiquitination.USP8hasbeenshowntodisruptthedown-regulationofmultiplereceptors,includingEGFR/ErbB1,ErbB2/Her2andSmoothened,viatheirdeubiquitination.Conversely,USP8appearstohavetheoppositeeffectonthetraffickingofCXCR4,PAR2,andtheδ-opioidreceptor.DepletionorcatalyticinactivationofUSP8stabilizedtheirexpression.Itisthoughtthatdeubiquitinationofthesereceptorsdown-streamofthesortingendosomecommitsthemtolysosomaldegradation.USP8canbephosphorylatedatSer680allowingfor14-3-3-epsilonbinding,whichsubsequentlyinhibitsUSP8activity.Additionally,USP8undergoestyrosinephosphorylationatitsN-terminusfollowingEGFactivationoftheEGFR/ErbB1/ErbB2/Her2receptorcomplex.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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