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Adipogen/USP7 (catalytic domain) (human) (rec.) (His)/AG-40T-0542-C050/50 µg
Adipogen/USP7 (catalytic domain) (human) (rec.) (His)/AG-40T-0542-C050/50 µg
商品编号：
AG-40T-0542-C050
品牌：
Adipogen Inc
市场价：
¥3860.00
美元价：
2316.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | UbiquitinC-terminalHydrolase7;DeubiquitinatingEnzyme7Herpesvirus-associatedUbiquitin-specificProtease;UbiquitinThioesterase7;UbiquitinSpecificProtease7;HAUSP |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanUSP7(catalyticdomainaa213-548)(AccessionNr.Q93009)fusedtoaN-terminalHis-tag. |
| Crossreactivity | Human |
| Formulation | Liquid.InHEPES,NaCl,DTTandGlycerol. |
| OtherProductData | Use:Ubiquitin-specificdeconjugatingenzyme.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof1-5nM.15minutepre-incubationwith10mMDTTisrecommendedtoachievemaximumactivity. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
UbiquitinSpecificPeptidase7(USP7),alsoknownasHerpesVirus-associatedubiquitinSpecificProtease(HAUSP),isawidelyexpresseddeubiquitinatingenzymebelongingtothepeptidaseC19family.Ithasapredictedmolecularweightof130kDa.HumanUSP7is1102aminoacids(aa)inlengthandshares99%aasequenceidentitywiththemouseandratorthologs.USP7consistsofacysteinepeptidasecore(aa208-560)thatisflankedbyanN-terminalTRAF-likedomain(aa50-205)andtwoC-terminalprotease-resistantdomains(aa622-801and885-1061).USP7canbephosphorylatedatSer18andSer963andubiquitinatedatLys869.USP7wasinitiallyidentifiedasap53-interactingproteinthatdeubiquitinatesp53,therebystabilizingtheproteinandinducingp53-dependentcellgrowtharrestandcancer.USP7alsotargetsthep53regulatoryproteinsMDM2,MDMX,andDaxx,theepigeneticregulatorhistone2B,andthetranscriptionfactorFoxO4.Additionally,USP7interactswiththeHSV-1immediateearlyproteinICP0,contributingtothestabilizationandtransactivationcapabilityofICP0duringHSV-1infection.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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