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Adipogen/USP28 (human) (rec.) (His)/AG-40T-0541-C100/100 µg
Adipogen/USP28 (human) (rec.) (His)/AG-40T-0541-C100/100 µg
商品编号：
AG-40T-0541-C100
品牌：
Adipogen Inc
市场价：
¥8740.00
美元价：
5244.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Ubiquitin C-terminal Hydrolase 28; Deubiquitinating Enzyme 28; Ubiquitin Thioesterase 28; Ubiquitin-specific-processing Protease 28 |
| Product Type | Protein |
| Properties | |
| Source/Host | Sf21 cells |
| Sequence | Human USP28 (Accession Nr. Q96RU2) fused to a C-terminal His-tag. |
| Crossreactivity | Human |
| Formulation | Liquid. In HEPES, NaCl and TCEP. |
| Other Product Data | Use: Ubiquitin-specific deconjugating enzyme. Reaction conditions will need to be optimized for each specific application. We recommend an initial protein concentration of 10-500nM. |
| Declaration | Manufactured by Boston Biochem |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -80°C |
| Handling Advice | Aliquot to avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -80°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
USP28 is a deubiquitinating enzyme of the C19 peptidase family that regulates MYC stability and DNA damage response checkpoints. USP28 regulates DNA repair by deubiquitinating and thereby stabilizing CLSPN, a protein that is ubiquitinated by the APC/C E3 ubiquitin ligase in a cell-cycle dependent manner. USP28 interacts with isoform 1 of FBXW7 in the nucleoplasm, and regulates MYC degradation by counteracting its ubiquitination. A potential role in HIF-1α-dependent processes such as angiogenesis and metastasis has been described for this deubiquitinase. USP28 has been demonstrated to cleave K6, K11, K48, and K63-linked poly-ubiquitin chains.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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