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Adipogen/USP22 (human) (rec.) (His)/AG-40T-0562-C050/50 µg
Adipogen/USP22 (human) (rec.) (His)/AG-40T-0562-C050/50 µg
商品编号：
AG-40T-0562-C050
品牌：
Adipogen Inc
市场价：
¥8740.00
美元价：
5244.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Ubiquitin C-terminal Hydrolase 22; Deubiquitinating Enzyme 22; Ubiquitin Thioesterase 22; Ubiquitin-specific-processing Protease 22 |
| Product Type | Protein |
| Properties | |
| Source/Host | Sf21 cells |
| Sequence | Human USP22 (Accession Nr. AAI26899.1) fused to N-terminal His-tag. |
| Crossreactivity | Human |
| MW | ~60kDa |
| Purity | ≥95% (SDS-PAGE) |
| Accession Number | AAI26899.1 |
| Formulation | Liquid. In 50mM HEPES pH 7.5, 100mM NaCl, 10% Glycerol (v/v) and 2mM TCEP. |
| Other Product Data |
Use: Ubiquitin-specific deconjugating enzyme. Reaction conditions will need to be optimized for each specific application. We recommend an initial protein concentration of 20-100nM when using Ubiquitin (human) (rec.) (AMC) (AG-40T-0459MC) or Ubiquitin (human) (rec.) (Rhodamine) (AG-40T-0459RH) as substrate. Note: Recombinant human USP22 is not active toward poly-Ubiquitin chains, ubiquitinated histones and other ubiquitinated protein substrates in the absence of adapter proteins such as ATXN7L or ENY2. |
| Declaration | Manufactured by Boston Biochem |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -80°C |
| Handling Advice | Aliquot to avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -80°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
USP22 is a member of the SAGA (Spt-Ada-Gcn5 acetyltransferase) complex, a 2 MDa protein machine that mediates the acetylation and deubiquitination of histones as well as non-histone substrates. Within SAGA, USP22 binds directly with ATXN7L3 and provides the activity required to deubiquitinate mono-ubiquitinated histone H2B. USP22 is required for nuclear receptor-mediated transactivation and cell cycle progression. Recent findings suggest USP27X and USP51, which function independently of SAGA may compete with USP22 for ATXN7L3 and ENY2 binding, and that imbalances in these activities may contribute to human diseases including cancer.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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