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Adipogen/USP12 (human) (rec.) (His)/AG-40T-0570-C050/50 µg
Adipogen/USP12 (human) (rec.) (His)/AG-40T-0570-C050/50 µg
商品编号：
AG-40T-0570-C050
品牌：
Adipogen Inc
市场价：
¥10700.00
美元价：
6420.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | UbiquitinCarboxyl-terminalHydrolase12;DeubiquitinatingEnzyme12;UbiquitinThioesterase12;Ubiquitin-specific-processingProtease12 |
| ProductType | Protein |
| Properties | |
| Source/Host | Sf21cells |
| Sequence | HumanUSP12(AccessionNr.NP_872294.2). |
| Crossreactivity | Human |
| MW | ~44kDa |
| Purity | ≥95%(SDS-PAGE) |
| Formulation | Liquid.In50mMHEPES,pH8.2,200mMNaCl,10%glycerol,2mMTCEP. |
| OtherProductData | Use:Reactionconditionswillneedtobeoptimizedforeachspecificapplication.WerecommendaninitialrecombinanthumanUSP12concentrationof50-500nMwhenusingUbiquitin-AMC(AG-40T-0459)orUbiquitin-Rh110(AG-40T-0459RH)substrates. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Ubiquitincarboxyl-terminalhydrolase12(USP12)isaspecializedcysteineproteasewithapredictedmolecularweightof43kDa.USP12isamemberofthepeptidaseC19familyandUSP12/USP46subfamily,andthehumanproteinshares98%aminoacidsequenceidentitywithitsmouseortholog.LikeUSP1andUSP46,USP12lacksappreciableactivityintheabsenceofitsco-activatorUAF1.AdditionofUAF1increasestheinvitroactivityofUSP1220-foldormore.WDR20isoftenfoundincomplexwithbothUSP12andUAF1,andtheternarycomplexisreportedtobemoreactivethantheUSP12/UAF1complex.BIOLOGically,USP12hasbeenimplicatedasapositiveregulatorofAndrogenReceptor(AR)activityviaamechanismthatinvolvesdown-regulationofAktactivity.Assuch,ithasbeenproposedthatUSP12inhibitioncouldofferatherapeutictargetforsomeformsofprostatecancer.ThisrecombinantproteincontainsaC-terminal6-Histag.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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