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Adipogen/UFM1 Activating Enzyme (human) (rec.) (His)/AG-40T-0533-C025/25 µg
Adipogen/UFM1 Activating Enzyme (human) (rec.) (His)/AG-40T-0533-C025/25 µg
商品编号：
AG-40T-0533-C025
品牌：
Adipogen Inc
市场价：
¥8740.00
美元价：
5244.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Ubiquitin-likeModifier-activatingEnzyme5;THIFP1;UBE1DC1;UBA5 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanUFM1ActivatingEnzyme(AccessionNr.Q9GZZ9)fusedtoaN-terminalHis-tag. |
| Crossreactivity | Human |
| Formulation | Liquid.In50mMHEPESpH7.5,100mMNaCl,1mMTCEP. |
| OtherProductData | Use:MemberoftheUFM1-activating(E1)enzymefamilythatisrequiredforthefirststepoftheenzymaticcascadethatsubsequentlyutilizesaUFM1-conjugating(E2)enzymeandaUFM1ligase(E3)toconjugateUFM1tosubstrateproteins.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof50-200nM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Ubiquitin-foldModifier1(UFM1)ActivatingEnzyme,alsoknownasubiquitin-likemodifieractivatingenzyme5(UBA5)andubiquitin-activatingenzymeE1domain-containingprotein1(UBE1DC1),isa404aminoacid(aa)memberoftheubiquitin-activating(E1)enzymefamilywithapredictedmolecularweightof45kDa.ThemouseandratUFM1ActivatingEnzyme/UBA5orthologsshare87%and88%aasequenceidentitywiththehumanprotein,respectively.UFM1ActivatingEnzyme/UBA5ishighlyconservedinplantsandmetazoansbutnotinyeast.Inhumans,itisexpressedbothasthefulllengthproteinandasatruncatedisoformthatlacksaa1-56.Itiswidelyexpressedinhumancellswhereitislocalizedtothecytoplasmandnucleus.UFM1ActivatingEnzyme/UBA5hasaconservedATP-bindingmotifincloseproximitytoanactivesitecysteineresidue,Cys250inhumans,andametalbindingmotif,bothofwhicharecommontomostE1enzymes.ItistheactivatingenzymeforbothUFM1andSUMO2.UFM1ActivatingEnzyme/UBA5isrequiredforerythroiddifferentiationinmice.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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