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Adipogen/Uev1a (human) (rec.) (His)/AG-40T-0527-C100/100 µg
Adipogen/Uev1a (human) (rec.) (His)/AG-40T-0527-C100/100 µg
商品编号：
AG-40T-0527-C100
品牌：
Adipogen Inc
市场价：
¥7440.00
美元价：
4464.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Ubiquitin-conjugatingEnzymeVariant1a;CIR1;CROC1;TRAF6-regulatedIKKActivator1βUev1A;Mms2;UBE2V1 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanUev1a(AccessionNr.Q13404)fusedtoaN-terminalHis-tag. |
| Crossreactivity | Human |
| Formulation | Liquid.In50mMHEPESpH7.5,200mMNaCl,10%Glycerol(v/v),1mMTCEP. |
| OtherProductData | Use:Memberoftheubiquitinconjugating(E2)enzymefamilythatreceivesubiquitinfromaubiquitinactivating(E1)enzymeandsubsequentlyinteractswithaubiquitinligase(E3)toconjugateubiquitintosubstrateproteins.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof0.1-1μM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Ubiquitin-conjugatingEnzymeVariant1a(Uev1a),alsoknownasubiquitin-conjugatingenzymeE2variant1(UBE2V1),isamemberoftheubiquitin-conjugating(E2)enzymefamily.HumanUev1a/UBE2V1anditsmouseorthologhavepredictedmolecularweightsof19kDaand16.5kDa,respectively.Thehumanproteinshares89%aminoacid(aa)sequenceidentitywithitsmouseortholog.TheE2catalyticcoredomainofUev1a/UBE2V1lacksanactivesitecysteineresidue,renderingitcatalyticallyinactiveonitsown.However,inthecytoplasmUev1a/UBE2V1isabletoformacatalyticallyactivecomplexwithUBE2N/Ubc13,whichmediatesthesynthesisLys63-linkedubiquitinchainsandisrequiredforNF-κBactivation.Uev1a/UBE2V1isrequiredforUBE2N(Ubc13)/Uev1aComplex-dependentLys63-linkedubiquitinchainformation.Morespecifically,Uev1a/UBE2V1orientstheubiquitinmoleculetofavorlinkageatLys63viaanon-covalentinteractionwiththeubiquitinmolecule.Thehumanproteincontainsanon-conserved30aaN-terminaltailthatfunctionallydifferentiatesitfromMms2,anotherE2enzymevariantandUBE2N/Ubc13bindingpartner.PharmacologicalinhibitionoftheUBE2N(Ubc13)/Uev1acomplexblockstheproliferationofdiffuselargeB-celllymphomacells,suggestingthatthiscomplexmayplayaroleincancer.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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