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Adipogen/Ubiquitin (phosphorylated) (pS65) (human) (rec.)/AG-40T-0555-C150/150 µg
Adipogen/Ubiquitin (phosphorylated) (pS65) (human) (rec.)/AG-40T-0555-C150/150 µg
商品编号：
AG-40T-0555-C150
品牌：
Adipogen Inc
市场价：
¥7960.00
美元价：
4776.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | UBB;UbiquitinB |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanUbiquitin(AccessionNr.P0CG47)phosphorylatedonSer65. |
| Crossreactivity | Human |
| MW | ~8.6kDa |
| Purity | ≥98%(SDS-PAGE) |
| PurityDetail | >95%byLC/MS(AQUA)analysis,<5% unmodified="" ubiquitin.=""> |
| Formulation | Liquid.In10mMHEPES,pH7.5. |
| OtherProductData | Use:Reactionconditionswillneedtobeoptimizedforeachspecificapplication. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Serine/ThreoninekinasePINK1(PTEN-inducedputativekinaseprotein1)playsacriticalroleinpreventingmitochondrialdysfunctionduringcellularstress.PINK1istranslatedinthecytosol,thentranslocatedtotheoutermitochondrialmembranewhereitisrapidlycleavedanddegradedasapartofnormalmitochondrialfunction.Indamaged(depolarized)mitochondriaPINK1becomesstabilizedandaccumulates,resultinginthesubsequentphosphorylationofnumerousproteinsonthemitochondrialsurfaceincludingMfn2.UltimatelyPARK2(E3UbiquitinLigaseParkin)isrecruitedtothedamagedmitochondriawhereitisactivatedbyPINK-mediatedphosphorylationofPARK2atserine65,andPARK2interactionwithphosphorylatedUbiquitin(alsophosphorylatedbyPINKonserine65).Thissignalingcascadeiscriticalforclearingthedamagedmitochondriaviaselectiveautophagy(mitophagy)bymediatingactivationandtranslocationofPARK2.
Ubiquitin(phosphorylated)(pS65)(human)(rec.)isgeneratedenzymaticallyusingPINK1kinasefromRedFlourBeetle(Triboliumcastaneum).
Ubiquitin(phosphorylated)(pS65)(human)(rec.)isgeneratedenzymaticallyusingPINK1kinasefromRedFlourBeetle(Triboliumcastaneum).
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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