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Adipogen/Ubiquilin 1 Tandem UBA [TUBE2] (human) (rec.) (His)/AG-40T-0453-C250/250 µg
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Adipogen/Ubiquilin 1 Tandem UBA [TUBE2] (human) (rec.) (His)/AG-40T-0453-C250/250 µg
商品编号：
AG-40T-0453-C250
品牌：
Adipogen Inc
市场价：
¥7960.00
美元价：
4776.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ProteinLinkingIAPwithCytoskeleton1;DA41;DSK2;PLIC-1;UBQLN1;UBQN;XDRP1 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | Humanubiquilin1TandemUBA[TUBE2](AccessionNr.Q9UMX0)fusedtoaHis-tag. |
| Crossreactivity | Human |
| Formulation | Liquid.In50mMHEPES,200mMNaCl,1mMDTTpH8.0. |
| OtherProductData | Use:CanbeusedfortheisolationandidentificationofK48-linked(preferentially)orK63-linkedpoly-ubiquitinchainsorubiquitinatedsubstratesthatcontaintheselinkages.Allowsformetalchelateaffinitypurificationandalsoallowsforconvenientimmuno-detectionofconjugatesusingHis-specificantibodies.Use50-100µgofproteintodetect2-25µgofpurifiedK48-linkedubiquitinchains.Theamountnecessaryforuseincrudelysatesneedstobedeterminedempirically. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Ubiquilin1isaubiquitouslyexpressedmemberoftheUBL-UBAfamilyofubiquitin-bindingproteinsthatis589aminoacids(aa)inlengthandhasapredictedmolecularweightof62.5kDa.Humanubiquilin1shares88%aasequenceidentitywiththemouseandratorthologs.ItcontainsaN-terminalubiquitin-like(UBL)domainandaC-terminalubiquitin-associated(UBA)domain.TheUBAdomainisabletointeractwithmono-andpoly-ubiquitinchains,withasimilaraffinityforLys48-andLys63-linkedchains.Incontrast,theUBLdomaininteractswithubiquitin-interactingmotif(UIM)-containingproteins,suchasS5a/Angiocidin,a19SProteasomecomponent.Itisthoughtthatubiquilin1mayactasamolecularshuttle,bringingpoly-ubiquitinatedproteinstothe26SProteasomebysimultaneouslybindingpoly-ubiquitinviaitsUBAdomainandthe19SProteasomeviaitsUBLdomain.Ubiquilin1alsobindstwoendoplasmicreticulum(ER)-localizedproteins,HerpandErasin,andmayfunctionintheER-associateddegradationpathway.Ithasbeenreportedtoco-precipitatewithLC3/MAP1LC3A/Apg8p3,anautophagosomalMarker,suggestingthatitmayplayaroleinautophagy.SinglenucleotidepolymorphismsintheUBQLN1genehavebeenlinkedtoAlzheimer"sdisease(AD).FurThermore,ubiquilin1mayregulatetheprocessingofAPP,whichisassociatedwithAD.Tandemubiquitinbindingentities(TUBEs)havebeendevelopedfortheisolationandidentificationofubiquitinatedproteins.TUBEsdisplayincreasedaffinityforpoly-ubiquitinmoietiesoverthesingleubiquitinbindingassociateddomain(UBA).TUBEsalsodisplayaprotectiveeffectonpoly-ubiquitinatedproteins,allowingfordetectionatrelativelylowabundance.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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