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Adipogen/Ubiquilin 1 Tandem UBA [TUBE2] (human) (rec.) (Agarose)/AG-40T-0451-R250/250 µl
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Adipogen/Ubiquilin 1 Tandem UBA [TUBE2] (human) (rec.) (Agarose)/AG-40T-0451-R250/250 µl
商品编号：
AG-40T-0451-R250
品牌：
Adipogen Inc
市场价：
¥5500.00
美元价：
3300.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ProteinLinkingIAPwithCytoskeleton1;DA41;DSK2;PLIC-1;UBQLN1;UBQN;XDRP1 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | Humanubiquilin1(TUBE2aa546-586)(AccessionNr.Q9UMX0)isconjugatedtoagarose. |
| Crossreactivity | Human |
| Label/Conjugates | Agarose |
| Formulation | Liquid.In50mMHEPES,pH7.5,250mMNaCl. |
| OtherProductData | Use:Thisaffinityresincanbeusedfortheenrichment,isolationandidentificationofK48-linked(preferentially)orK63-linkedpoly-ubiquitinchainsorubiquitinatedsubstratesthatcontaintheselinkages.Equilibrateresinbywashingwith5-10mldesiredstartbuffer.Bindingandelutionofmaterialisdependentonindividualexperimentalconditions. Storage:Theagarosecanbere-usedforatleast2applicationsifproperlymaintained.Afteruse,cleanresinwith5ml50mMTrispH9.0,1MKCl.Removecleaningsolutionbywashingresinwith5mlstoragebuffer. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Donotfreeze. |
| Use/StABIlity | Stableforatleast3monthsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Ubiquilin1isaubiquitouslyexpressedmemberoftheUBL-UBAfamilyofubiquitin-bindingproteinsthatis589aminoacids(aa)inlengthandhasapredictedmolecularweightof62.5kDa.HumanUbiquilin1shares88%aasequenceidentitywiththemouseandratorthologs.ItcontainsaN-terminalubiquitin-like(UBL)domainandaC-terminalubiquitin-associated(UBA)domain.TheUBAdomainisabletointeractwithmono-andpoly-ubiquitinchains,withasimilaraffinityforLys48-andLys63-linkedchains.Incontrast,theUBLdomaininteractswithubiquitin-interactingmotif(UIM)-containingproteins,suchasS5a/Angiocidin,a19SProteasomecomponent.ItisthoughtthatUbiquilin1mayactasamolecularshuttle,bringingpoly-ubiquitinatedproteinstothe26SProteasomebysimultaneouslybindingpoly-ubiquitinviaitsUBAdomainandthe19SProteasomeviaitsUBLdomain.Ubiquilin1alsobindstwoendoplasmicreticulum(ER)-localizedproteins,HerpandErasin,andmayfunctionintheER-associateddegradationpathway.Ithasbeenreportedtoco-precipitatewithLC3/MAP1LC3A/Apg8p3,anautophagosomalMarker,suggestingthatitmayplayaroleinautophagy.SinglenucleotidepolymorphismsintheUBQLN1genehavebeenlinkedtoAlzheimer"sdisease(AD).FurThermore,Ubiquilin1mayregulatetheprocessingofAPP,whichisassociatedwithAD.TandemubiquitinBindingEntities(TUBEs)havebeendevelopedfortheisolationandidentificationofubiquitinatedproteins.TUBEsdisplayincreasedaffinityforpoly-ubiquitinmoietiesoverthesingleubiquitinbindingassociateddomain(UBA).TUBEsalsodisplayaprotectiveeffectonpoly-ubiquitinatedproteins,allowingfordetectionatrelativelylowabundance.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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