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当前位置: 首页 > 产品中心 > Other_recombinant_protein > Adipogen/UBE3A (human) (rec.) (His)/AG-40T-0450-C050/50 µg
商品详细Adipogen/UBE3A (human) (rec.) (His)/AG-40T-0450-C050/50 µg
Adipogen/UBE3A (human) (rec.) (His)/AG-40T-0450-C050/50 µg
Adipogen/UBE3A (human) (rec.) (His)/AG-40T-0450-C050/50 µg
商品编号: AG-40T-0450-C050
品牌: Adipogen Inc
市场价: ¥9060.00
美元价: 5436.00
产地: 美国(厂家直采)
公司:
产品分类: 其它重组蛋白
公司分类: Other_recombinant_protein
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
MoreInformation
ProductDetails
SynonymsUbiquitin-proteinLigaseE3A;E6AP;HumanPapillomavirusE6-associatedProtein;ANCR;EPVE6AP;HPVE6A;OncogenicProtein-associatedProteinE6-AP;RenalCarcinomaAntigenNY-REN-54
ProductTypeProtein
Properties
Source/HostSf21cells
SequenceHumanUBE3A(AccessionNr.Q05086)fusedtoaC-terminalHis-tag.
CrossreactivityHuman
FormulationLiquid.In50mMHEPESpH8.0,100mMNaCl,1mMTCEP.
OtherProductDataUse:Typicalenzymeconcentrationtosupportconjugationinvitrois1-5μMdependingonexperimentalconditions.
DeclarationManufacturedbyBostonBiochem
ShippingandHandling
ShippingDRYICE
ShortTermStorage-20°C
LongTermStorage-80°C
HandlingAdviceAliquottoavoidfreeze/thawcycles.
Use/StABIlityStableforatleast1yearafterreceiptwhenstoredat-80°C.
Documents
MSDSNo
ProductSpecificationSheet
DatasheetDownloadPDF
UBE3A,alsocalledE6AP(E6-AssociatedProtein)isaHECTdomainubiquitinE3ligasethatubiquitinatesandmediatestheproteasomaldestructionofsubstrateproteins.HECTdomainligasesuseanactivesitecysteinetoacceptchargedubiquitinfromubiquitin-E2thioestercomplexesforsubsequenttransfertosubstrateproteins.InthiswayHECTclassligasesaredistinctfrommostRINGclassligasesinthatthelatterfacilitatetransferofubiquitinfromchargedE2’sdirectlytosubstrateproteinswithoutanE3-ubiquitinthioesterintermediate.TheviralHPV-E6protein(presentincellsinfectedwithhumanpapillomavirus)formsacomplexwithE6APtogeneratealigaseactivitythatpolyubiquitinatesthetumorsuppressorsp53andp73andtargetsthemtothe26Sproteasomefordegradation.
品牌介绍
Adipogen公司由三个子公司组成,分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国,运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发,如癌症、免疫、炎症、代谢疾病(糖尿病、肥胖)、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外,也可提供抗体和蛋白产品,Adipogen拥有自己的化学实验室,致力于开发创新型小分子化合物。