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Adipogen/UBE2W Isoform 1 (human) (rec.) (His)/AG-40T-0447-C100/100 µg
Adipogen/UBE2W Isoform 1 (human) (rec.) (His)/AG-40T-0447-C100/100 µg
商品编号：
AG-40T-0447-C100
品牌：
Adipogen Inc
市场价：
¥7440.00
美元价：
4464.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Ubiquitin-conjugating Enzyme E2 W; Ubc16; N-terminus-conjugating E2; Ubiquitin-protein Ligase W |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence | Human UBE2W Isoform 1 (Accession Nr. Q96B02-1) fused to a N-terminal His-tag. |
| Crossreactivity | Human |
| Formulation | Liquid. In 50mM MOPS pH 6.5, 150mM NaCl and 2mM TCEP. |
| Other Product Data | Use: Member of the ubiquitinconjugating (E2) enzyme family that receives ubiquitin from a ubiquitinactivating (E1) enzyme and subsequently interacts with a ubiquitin ligase (E3) to conjugate ubiquitin to substrate proteins. Reaction conditions will need to be optimized for each specific application. We recommend an initial protein concentration of 0.1-1μM. |
| Declaration | Manufactured by Boston Biochem |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -80°C |
| Handling Advice | Aliquot to avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -80°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Ubiquitin-conjugating Enzyme E2W (UBE2W), also known as ubiquitin-conjugating enzyme 16 (UBC16), is a member of the ubiquitin-conjugating (E2) enzyme family. It has an E2 catalytic core domain with an active site cysteine residue that is required for the formation of a thioester bond with ubiquitin. There are two isoforms of UBE2W, isoform 1 and isoform 2, with predicted molecular weights of 18.1 kDa and 19.5 kDa, respectively. UBE2W localizes to the nucleus where it promotes the mono-ubiquitination of BRCA1 and FANCD2, both of which contribute to DNA repair pathways. Mono-ubiquitination of the CHIP ubiquitin ligase (E3), which has been reported to enhance its E3 ligase activity, is also mediated by UBE2W.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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