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Adipogen/UBE2J1 (human) (rec.) (His)/AG-40T-0438-C100/100 µg
Adipogen/UBE2J1 (human) (rec.) (His)/AG-40T-0438-C100/100 µg
商品编号：
AG-40T-0438-C100
品牌：
Adipogen Inc
市场价：
¥7440.00
美元价：
4464.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Ubiquitin-conjugatingEnzymeE2J1;CGI-76;HSPC153;NCUBE1;UBC6e;Non-canonicalUbiquitin-conjugatingEnzyme1;YeastUbiquitin-conjugatingEnzymeUBC6HomologE |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanUBE2J1(AccessionNr.Q9Y385)fusedtoaN-terminalHis-tag. |
| Crossreactivity | Human |
| Formulation | Liquid.In50mMHEPESpH8.0,200mMNaCl,10%Glycerol(v/v),1mMTCEP. |
| OtherProductData | Use:Memberoftheubiquitinconjugating(E2)enzymefamilythatreceivesubiquitinfromaubiquitinactivating(E1)enzymeandsubsequentlyinteractswithaubiquitinligase(E3)toconjugateubiquitintosubstrateproteins.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof0.1-1μM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Ubiquitin-conjugatingEnzymeE2,J1(UBE2J1),alsoknownasHsUbc6e,isa318aminoacid(aa)memberoftheubiquitin-conjugating(E2)enzymefamilywithapredictedmolecularweightofapproximately35kDa.Thehumanproteinshares92%and85%aasequenceidentitywiththemouseandratorthologs,respectively.UBE2J1hasanE2catalyticcoredomainwithanactivesitecysteineresiduethatisrequiredfortheformationofathioesterbondwithubiquitin.Itlocalizestoendoplasmicreticulum(ER)membraneswhereitparticipatesinER-associateddegradation(ERAD)ofmisfoldedproteins.InresponsetoERstress,UBE2J1isphosphorylatedonSer184inaPERK-dependentmanner.IthasalsobeenshowntofunctionwiththeHRD1ubiquitinligase(E3)topromotetheubiquitinationanddegradationofmisfoldedMHCclassIheavychainviaERAD.Additionally,UBE2J1mayhaveapreventativeroleinearly-onsetsystemicamyloidosis.Ithasaredundantrole,alongwiththeUBE2G2E2enzyme,inpromotingthedegradationofamutantformoftransthyretinthatisassociatedwiththisdisease.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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