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Adipogen/UBE1 (human) (rec.) (His)/AG-40T-0431-C050/50 µg
Adipogen/UBE1 (human) (rec.) (His)/AG-40T-0431-C050/50 µg
商品编号：
AG-40T-0431-C050
品牌：
Adipogen Inc
市场价：
¥5820.00
美元价：
3492.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | UbiquitinE1Enzyme;UbiquitinActivatingEnzymeE1;Ubiquitin-likeModifier-activatingEnzyme1;A1S9T;AMCX1;GXP1;POC20;SMAX2;UBA1 |
| ProductType | Protein |
| Properties | |
| Source/Host | Sf21cells |
| Sequence | HumanUBE1(AccessionNr.P22314)fusedtoaN-terminalHis-tag. |
| Crossreactivity | Human |
| MW | ~121kDa |
| Purity | ≥95%(SDS-PAGE) |
| Formulation | Liquid.In50mMHEPESpH8.0,50mMNaCl,1mMTCEP. |
| OtherProductData | Use:Memberoftheubiquitin-activating(E1)enzymefamilythatisrequiredforthefirststepoftheenzymaticcascadethatsubsequentlyutilizesaubiquitin-conjugating(E2)enzymeandaubiquitinligase(E3)toconjugateubiquitintosubstrateproteins.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof50-200nM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Ubiquitin-activatingEnzyme(UBE1),alsoknownasubiquitin-likemodifieractivatingenzyme1(UBA1),isa1058aminoacid(aa)canonicalmemberoftheubiquitin-activating(E1)enzymefamilyofproteinswithapredictedmolecularweightof118kDa.Itisubiquitouslyexpressedandhighlyconserved;mouseandratUBE1share95%and96%aasequenceidentitywiththehumanUBE1protein,respectively.UBE1isfoundinthecytoplasmandnucleus,andcontainsaconservedactive-sitecysteineresidueandATP-bindingsitecommontoE1enzymes.UBE1isresponsIBLeforthefirststepinubiquitin-proteinisopeptidebondformation.UbiquitinisactivatedbyUBE1andthereafterlinkedtothesidechainofacysteineresidueinUBE1,Cys632inhumans,yieldingaubiquitin-UBE1conjugateviaathioesterbond.Theactivatedubiquitinisthentransferredtoalysineresidueonthetargetproteinviatheubiquitin-conjugating–ubiquitinligaseenzymecascade.UBE1isrequiredforcellcycleprogressionandhasbeenlinkedtocellularresponsestoDNAdamagesuchasnucleotideexcisionrepair.MutationsinUBE1areassociatedwithX-linkedlethalinfantilespinalmuscularatrophy.UBE1isacriticalcomponentfortheinitiationofinvitroubiquitinconjugationreactions.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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