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Adipogen/UbcH8 (human) (rec.) (GST)/AG-40T-0428-C100/100 µg
Adipogen/UbcH8 (human) (rec.) (GST)/AG-40T-0428-C100/100 µg
商品编号：
AG-40T-0428-C100
品牌：
Adipogen Inc
市场价：
¥7440.00
美元价：
4464.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Ubiquitin-conjugating Enzyme H8; RIG-B; Ubiquitin/ISG15-conjugating Enzyme E2 L6; Ubiquitin-protein Ligase L6; UBE2L6 |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence | Human UbcH8 (Accession Nr. O14933) fused to a N-terminal GST-tag. |
| Crossreactivity | Human |
| Formulation | Liquid. In 50mM HEPES pH 7.5, 100mM NaCl, 10% Glycerol (v/v), 1mM TCEP. |
| Other Product Data | Use: Member of the ubiquitin and ISG15conjugating (E2) enzyme family that receives ubiquitin and ISG15 from a ubiquitin and ISG15activating (E1) enzyme and subsequently interacts with a ubiquitin and ISG15 ligase (E3) to conjugate ubiquitin and ISG15 to substrate proteins. Reaction conditions will need to be optimized for each specific application. We recommend an initial protein concentration of 0.1-1μM. |
| Declaration | Manufactured by Boston Biochem |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -80°C |
| Handling Advice | Aliquot to avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -80°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Ubiquitin-conjugating Enzyme H8 (UbcH8), also known as ubiquitin-conjugating Enzyme E2L 6 (UBE2L6), has a predicted molecular weight of 18 kDa. Human UbcH8 shares 76% and 74% amino acid sequence identity with mouse and rat UBE2L6, respectively. UbcH8 is capable of transferring either ubiquitin or the ubiquitin-like protein ISG15 ubiquitin-like modifier (ISG15) to target proteins. ISG15 conjugation is mediated by UbcH8 following IFN-α or IFN-β stimulation. UbcH8 interacts with a variety of ubiquitin ligases (E3s) to transfer ubiquitin to target proteins such as the cell cycle regulator, p21/CIP1/CDKN1A. UbcH8 also regulates actin cytoskeleton dynamics, and dysregulated UbcH8 promotes migration and invasion of human breast cancer cells. In addition, UbcH8 interacts with the E3, Parkin, and is thought to play a role in the pathogenesis of Parkinson’s disease.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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