脂肪原/UbcH8（人类）（记录）/AG-40T-0427-C100/100µg
商品编号：
AG-40T-0427-C100
品牌：
Adipogen Inc
市场价：
¥7440.00
美元价：
4464.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Ubiquitin-conjugatingEnzymeH8;RIG-B;Ubiquitin/ISG15-conjugatingEnzymeE2L6;Ubiquitin-proteinLigaseL6;UBE2L6 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanUbcH8(AccessionNr.O14933). |
| Crossreactivity | Human |
| Formulation | Liquid.In50mMHEPESpH7.5,100mMNaCl,10%Glycerol(v/v),1mMTCEP. |
| OtherProductData | Use:MemberoftheubiquitinandISG15conjugating(E2)enzymefamilythatreceivesubiquitinandISG15fromaubiquitinandISG15activating(E1)enzymeandsubsequentlyinteractswithaubiquitinandISG15ligase(E3)toconjugateubiquitinandISG15tosubstrateproteins.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof0.1-1μM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Ubiquitin-conjugatingEnzymeH8(UbcH8),alsoknownasubiquitin-conjugatingEnzymeE2L6(UBE2L6),hasapredictedmolecularweightof18kDa.HumanUbcH8shares76%and74%aminoacidsequenceidentitywithmouseandratUBE2L6,respectively.UbcH8iscapableoftransferringeitherubiquitinortheubiquitin-likeproteinISG15ubiquitin-likemodifier(ISG15)totargetproteins.ISG15conjugationismediatedbyUbcH8followingIFN-αorIFN-βstimulation.UbcH8interactswithavarietyofubiquitinligases(E3s)totransferubiquitintotargetproteinssuchasthecellcycleregulator,p21/CIP1/CDKN1A.UbcH8alsoregulatesactinCytoskeletondynamics,anddysregulatedUbcH8promotesmigrationandinvasionofhumanbreastcancercells.Inaddition,UbcH8interactswiththeE3,Parkin,andisthoughttoplayaroleinthepathogenesisofParkinson’sdisease.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
