Adipogen/Ubc9 (human) (rec.)/AG-40T-0408-C100/100 µg
商品编号：
AG-40T-0408-C100
品牌：
Adipogen Inc
市场价：
¥7440.00
美元价：
4464.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Ubiquitin-conjugatingEnzymeE2I;p18;SUMO-proteinLigase;Ubc9;UBCE9;Ubiquitin-proteinLigaseI;UBE2I |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanUbc9(AccessionNr.P63279). |
| Crossreactivity | Human |
| MW | ~20kDa |
| Purity | ≥95%(SDS-PAGE) |
| Formulation | Liquid.In50mMHEPESpH7.5,100mMNaCl,10%Glycerol(v/v),1mMTCEP. |
| OtherProductData | Use:MemberoftheSUMOconjugating(E2)enzymefamilythatreceivesSUMOfromaSUMOactivating(E1)enzymeandsubsequentlyconjugatesSUMOtosubstrateproteins.ASUMOligase(E3)issometimesutilizedforSUMOconjugation,butisnotalwaysrequired.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof0.1-1μM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Ubiquitin-conjugatingEnzymeE2I(UBE2I),alsoknownasubiquitin-conjugatingenzyme9(Ubc9),isaubiquitouslyexpressedproteinwithapredictedmolecularweightof20kDa.HumanUBE2I/Ubc9shares100%aminoacidsequenceidentitywiththemouseandratorthologs.UBE2I/Ubc9catalyzestheadditionoftheubiquitin-likeproteinSUMOtotargetproteins.SUMOistransferredfromaubiquitin-likeactivating(E1)enzymeheterodimerconsistingofSAE1andUBA2toCys93ofUBE2I/Ubc9.Incontrasttomostubiquitin-conjugating(E2)enzymesthatfunctioninacomplexwithubiquitinligases(E3s),UBE2I/Ubc9caninteractdirectlywithproteinsubstratesandmayalsoplayaroleinsubstraterecognition.UBE2I/Ubc9mediatestheSUMOylationofavarietyofproteinsincludingRanGAP1,HDAC4andPML.Post-translationalmodificationsofUBE2I/Ubc9,suchasauto-SUMOylationatLys14orSer71phosphorylationbyCDC2/CDK1,alterUBE2I/Ubc9catalyticactivityandtargetproteinrecognition.UBE2I/Ubc9-dependentSUMOylationreducesthelevelsofthestemcellMarkerNanog,implicatingitinembryonicstemcellpluripotencymaintenance.SUMOylationalsoregulatestheproteinlevelsoftumorsuppressorsandoncogenes,andUBE2I/Ubc9dysregulationisthoughttocontributetothepathogenesisofhumancancers.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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