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Adipogen/Ubc13/UBE2V2 Complex (human) (rec.) (His)/AG-40T-0549-C100/100 µg
Adipogen/Ubc13/UBE2V2 Complex (human) (rec.) (His)/AG-40T-0549-C100/100 µg
商品编号：
AG-40T-0549-C100
品牌：
Adipogen Inc
市场价：
¥7440.00
美元价：
4464.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | UBE2N/UBE2V2 Complex |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence | Human Ubc13/UBE2V2 Complex (Accession Nr. Ubc13 | UBE2V2 ) fused to a N-terminal His-tag. |
| Crossreactivity | Human |
| MW | ~18kDa (Ubc13), ~17kDa (UBE2V2) |
| Purity | ≥95% (SDS-PAGE) |
| Formulation | Liquid. In 50mM HEPES pH7.5, 200mM NaCl, 10% Glycerol (v/v), 2mM TCEP. |
| Other Product Data | Use: Member of the ubiquitinconjugating (E2) enzyme family that receives ubiquitin from a ubiquitinactivating (E1) enzyme and subsequently interacts with a ubiquitin ligase (E3) to conjugate ubiquitin to substrate proteins. Reaction conditions will need to be optimized for each specific application. We recommend an initial protein concentration of 0.1-1μM. |
| Declaration | Manufactured by Boston Biochem |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -80°C |
| Handling Advice | Aliquot to avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -80°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Ubiquitinconjugating Enzyme E2N (UBE2N), also known as ubiquitinconjugating enzyme 13 (Ubc13), forms a functional complex with the catalytically inactive UBE2V2 (human homologue of yeast MMS2) protein. Human UBE2N/Ubc13 shares 100% and 99% amino acid (aa) sequence identity with the mouse and rat orthologs, respectively, while human UBE2V2 shares 99% aa sequence identity with its mouse and rat orthologs. The UBE2N/UBE2V2 Complex functions with ubiquitin ligases (E3s), including RNF111 and RNF8, to synthesize Lys63linked ubiquitin chains that can either be unanchored or attached to target proteins. The UBE2N/UBE2V2 complex has important roles in facilitating responses to various forms of DNA damage.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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