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Adipogen/Tri-ubiquitin [Ub3] WT Chains (K11-linked) (human) (rec.)/AG-40T-0569-C025/25 µg
![Adipogen/Tri-ubiquitin [Ub3] WT Chains (K11-linked) (human) (rec.)/AG-40T-0569-C025/25 µg](https://www.ebiomall.cn/images/adipogen/adipogen_logo_bw_2.png){kind=logo}
Adipogen/Tri-ubiquitin [Ub3] WT Chains (K11-linked) (human) (rec.)/AG-40T-0569-C025/25 µg
商品编号：
AG-40T-0569-C025
品牌：
Adipogen Inc
市场价：
¥6660.00
美元价：
3996.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence | Three human ubiquitin (Accession Nr. P0CG47) covalently linked through isopeptide bonds at K11 residues of one ubiquitin molecule and the C-terminal glycine residue of another ubiquitin molecule. |
| Crossreactivity | Human |
| MW | ~26kDa |
| Purity | ≥95% (SDS-PAGE) |
| Concentration | 1mg/ml |
| Formulation | Liquid. In sterile, deionized water. |
| Other Product Data |
Use: Formed with wild-type human recombinant ubiquitin and linkage-specific enzymes. Validated by Ub-AQUA, an LCMS-based technique that provides extremely accurate information on the composition of Poly-ubiquitin samples. Linkage-specific tri-ubiquitin can be used as a substrate for enzymes that cleave the isopeptide linkage between ubiquitin molecules. It can also be used to investigate mechanism of binding and recognition by E1 or E2 enzymes, deubiquitinating enzymes (DUBs), E3 ligases or other proteins that contain ubiquitin-associated domains (UBAs) or ubiquitin-interacting motifs (UIMs). Ideal for investigating ubiquitin-binding proteins and as substrates for ubiquitin-specific isopeptidases. Reaction conditions will need to be optimized for each specific application. IMPORTANT: Heating this product in SDS-PAGE buffer or terminating reactions containing this product with heated SDS-PAGE buffer could lead to unexpected, high apparent molecular weight banding or smearing on gels that is not representative of product purity. For optimal results, we recommend incubation in SDS-PAGE buffer + DTT at <40°c for="" 20="" minutes="" prior="" to="" gel="" electrophoresis.=""> |
| Declaration | Manufactured by Boston Biochem |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -80°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -80°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
With a predicted molecular weight of 26 kDa, tri-ubiquitin chains are composed of three ubiquitin monomers that are covalently linked through isopeptide bonds, which typically form between a lysine residue of one ubiquitin molecule and the C-terminal glycine residue of another ubiquitin. Each human ubiquitin monomer is 76 amino acids (aa) in length and shares 96% and 100% aa sequence identity with yeast and mouse ubiquitin, respectively. Seven of the 76 aa in ubiquitin are lysine residues that can participate in poly-ubiquitin chain formation. Linkage through specific lysine residues is thought to serve as a signal that affects protein degradation, signaling, trafficking and other cellular processes.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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