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Adipogen/TRAIL, Soluble (human) (rec.)/AG-40B-0003-C010/10 µg
Adipogen/TRAIL, Soluble (human) (rec.)/AG-40B-0003-C010/10 µg
商品编号：
AG-40B-0003-C010
品牌：
Adipogen Inc
市场价：
¥1400.00
美元价：
840.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Apo-2L;TNFSF10;CD253 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | TheextracellulardomainofhumanTRAIL(aa95-281)isfusedattheN-terminustoaFLAG®-tag. |
| Crossreactivity | Human Mouse |
| BIOLOGicalActivity | InducesapoptosisofhumanJurkatTcellsinaconcentrationrangeof5-50ng/mlinthepresenceof1μg/mlTNFLigandsEnhancer(Prod.No.AG-35B-0001).IntheabsenceofTNFLigandsEnhancer,TRAIL,Soluble(human)(recombinant)ispoorlyactive. |
| MW | ~23kDa(SDS-PAGE) |
| Purity | ≥95%(SDS-PAGE) |
| EndotoxinContent | <0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | 0.1mg/mlafterreconstitution. |
| Reconstitution | Reconstitutewith100μlsterilewater. |
| Formulation | Lyophilized.ContainsPBS. |
| OtherProductData | UniProtlinkP50591:TRAIL(human) AfCSSignallingGatewaylinkA002862:TRAIL(mouse) |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
TNF-relatedapoptosis-inducingligand(TRAIL;Apo2L;CD253;TNFSF10)isatypeIItransmembraneproteinofabout34kDa.Likemostmembersofthetumornecrosisfactor(TNF)superfamilyofcytokinesTRAILcanbecleavedatthecellsurfacebymetalloproteasestoformasolublemolecule.ActiveTRAILformstrimersandspecificallybindstofivedistinctreceptors:TRAIL-R1(DR4;Apo2;CD261;TNFRSF10A),TRAIL-R2(DR5;KILLER;TRICK2A;TRICK2B;CD262;TNFRSF10B),TRAIL-R3(DcR1;LIT;TRID;CD263;TNFRSF10C),TRAIL-R4(DcR2;TRUNDD;CD264;TNFRSF10D),andosteoprotegerin(OPG;OCIF;TNFRSF11B).TrimerizedTRAILtriggersapoptosisuponligationofcellsurfaceTRAIL-R1and/orTRAIL-R2byinducingtheformationoftheso-calledmultiproteindeath-inducingsignalingcomplex(DISC).
ProductReferences
TNF-RelatedApoptosis-InducingLigand(TRAIL)-ArmedExosomesDeliverProapoptoticSignalstoTumorSite:L.Rivoltini,etal.;Clin.CancerRes.22,3499(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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