脂肪原/肿瘤坏死因子-α(小鼠）（多聚体）（记录）/AG-40B-0021-C010/10µg
商品编号：
AG-40B-0021-C010
品牌：
Adipogen Inc
市场价：
¥3600.00
美元价：
2160.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | MultimericTNF-α™;ACRP30headless:TNF-α;ACRP30headless:TNFSF2;ACRP30headless:TumorNecrosisFactor-α |
| ProductType | Protein |
| Properties | |
| Source/Host | HEK293cells |
| Sequence | TheextracellulardomainofmouseTNF-α(aa77-235)isfusedattheN-terminustomouseACRP30headless(aa18-111)andaFLAG®-tag. |
| Crossreactivity | Human Mouse |
| Specificity | BindstohumanandmouseTNF-R1andTNF-R2. |
| BIOLOGicalActivity | ActivateshumanandmouseTNF-R1andTNF-R2.Inducescelldeathataconcentrationrangeof0.01-10ng/ml(ED50=0.05ng/mlor2x10E7Units/mg;WEHI164cells). |
| MW | ~34kDa(SDS-PAGE) |
| Purity | ≥95%(SDS-PAGE) |
| EndotoxinContent | <0.02EU/μgpurifiedprotein(LALtest;Lonza). |
| Concentration | 0.1mg/mlafterreconstitution. |
| Reconstitution | Reconstitutewith100μlsterilewater. |
| Formulation | Lyophilized.ContainsPBS. |
| OtherProductData | UniProtlinkP06804:TNF-α(mouse) FLAGisaregisteredtrademarkofSigma-AldrichCo. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Tumornecrosisfactor(TNF,cachexinorcachectinandformerlyknownastumornecrosisfactor-α)isacytokineinvolvedinsystemicinflammationandisamemberofagroupofcytokinesthatstimulatetheacutephasereaction.MultimericTNF-α™isahighactivityconstructinwhichtwotrimericTNF-αligandsareartificiallylinkedviathecollagendomainofACRP30.ThereceptorTNF-R1isactivatedbyboththemembrane-boundandsolubletrimericformsofTNF-α,whereasthereceptorTNF-R2onlyrespondstothemembrane-boundformofTNF-α(TNF-α(mouse)(multimeric)(rec.)(Prod.No.AG-40B-0021).SincetheMultimericTNF-α™mimicsthemembrane-boundform(formsoligomershigherthantrimer),itistheonlyTNF-αproteinthatcanactivatetheTNF-R2.ForTNF-R1activation,either"normal"TNF-αorMultimericTNF-α™canbeused.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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