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Adipogen/Tim-3 (human):Fc (mouse) (rec.)/CHI-HF-211T3-C100/100 µg
Adipogen/Tim-3 (human):Fc (mouse) (rec.)/CHI-HF-211T3-C100/100 µg
商品编号：
CHI-HF-211T3-C100
品牌：
Adipogen Inc
市场价：
¥7800.00
美元价：
4680.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | TIM3;TIMD3;HepatitisAVirusCellularReceptor2;HAVcr-2;TCellImmunoglobulinandMucinDomain-containingProtein3 |
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | TheextracellulardomainofhumanTim-3(aa22-200)isfusedtotheN-terminusoftheFcregionofmouseIgG2a. |
| Crossreactivity | Human |
| BIOLOGicalActivity | MeasuredbyitsbindingABIlityinafunctionalELISA. |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstitutewith100µlsterilewater.Add1XPBStothedesiredproteinconcentration. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | NCBIreferenceNP_116171.3:Tim-3(human) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/Stability | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
TheTIM(Tcell/transmembrane,immunoglobulinandmucin)familyplaysacriticalroleinregulatingimmuneresponses,includingallergy,asthma,transplanttolerance,autoimmunityandtheresponsetoviralinfections.TheuniquestructureofTIMimmunoglobulinvariableregiondomainsallowshighlyspecificrecognitionofphosphatidylserine(PtdSer),exposedonthesurfaceofapoptoticcells.Tim-3,atypeItransmembraneprotein,containsanimmunoglobulinandamucin-likedomaininitsextracellularportionandatyrosinephosphorylationmotifinitscytoplasmicportion.TIM-3ispreferentiallyexpressedonTh1andTc1cells,andgeneratesaninhibitorysignalresultinginapoptosisofTh1andTc1cells.TIM-3isalsoexpressedonsomedendriticcellsandcanmediatephagocytosisofapoptoticcellsandcross-presentationofantigen.Tim-3functionstoinhibitaggressiveTh1-mediatedauto-andalloimmuneresponses.Tim-3pathwayblockadebyadmiNISTrationofTim-3:Fcfusionproteinacceleratesdiabetesinnonobesediabeticmice,causeshyperproliferationofTh1cellsandTh1cytokinereleaseinanexperimentalautoimmuneencephalomyelitis(EAE)modelandpreventsacquisitionoftransplantationtoleranceinducedbycostimulationblockade.
ProductReferences
- Tim-3inhibitsThelpertype1-mediatedauto-andalloimmuneresponsesandpromotesimmunologicaltolerance:A.Sanchez-Fueyo,etal.;Nat.Immunol.4,1093(2003)
- Tim3bindingtogalectin-9stimulatesantimicrobialimmunity:P.Jayaraman,etal.;J.Exp.Med.207,2343(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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