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当前位置: 首页 > 产品中心 > Other_recombinant_protein > Adipogen/Super<i>Killer</i>TRAIL™, Soluble (human) (rec.)/AG-40T-0002-3020/3 x 20 µg
商品详细Adipogen/Super<i>Killer</i>TRAIL™, Soluble (human) (rec.)/AG-40T-0002-3020/3 x 20 µg
Adipogen/Super<i>Killer</i>TRAIL™, Soluble (human) (rec.)/AG-40T-0002-3020/3 x 20 µg
Adipogen/Super<i>Killer</i>TRAIL™, Soluble (human) (rec.)/AG-40T-0002-3020/3 x 20 µg
商品编号: AG-40T-0002-3020
品牌: Adipogen Inc
市场价: ¥13600.00
美元价: 8160.00
产地: 美国(厂家直采)
公司:
产品分类: 其它重组蛋白
公司分类: Other_recombinant_protein
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
TNF-relatedapoptosis-inducingligand(TRAIL;Apo2L;CD253;TNFSF10)isatypeIItransmembraneproteinofabout34kDa.Likemostmembersofthetumornecrosisfactor(TNF)superfamilyofcytokinesTRAILcanbecleavedatthecellsurfacebymetalloproteasestoformasolublemolecule.ActiveTRAILformstrimersandspecificallybindstofivedistinctreceptors:TRAIL-R1(DR4;Apo2;CD261;TNFRSF10A),TRAIL-R2(DR5;KILLER;TRICK2A;TRICK2B;CD262;TNFRSF10B),TRAIL-R3(DcR1;LIT;TRID;CD263;TNFRSF10C),TRAIL-R4(DcR2;TRUNDD;CD264;TNFRSF10D),andosteoprotegerin(OPG;OCIF;TNFRSF11B).TrimerizedTRAILtriggersapoptosisuponligationofcellsurfaceTRAIL-R1and/orTRAIL-R2byinducingtheformationoftheso-calledmultiproteindeath-inducingsignalingcomplex(DISC).
品牌介绍
Adipogen公司由三个子公司组成,分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国,运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发,如癌症、免疫、炎症、代谢疾病(糖尿病、肥胖)、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外,也可提供抗体和蛋白产品,Adipogen拥有自己的化学实验室,致力于开发创新型小分子化合物。
MoreInformation
ProductDetails
SynonymsTRAIL;Apo-2L;TNFSF10;CD253
ProductTypeProtein
Properties
Source/HostE.coli
SequenceTheextracellulardomainofhumanTRAIL(aa95-281)isfusedattheN-terminustoaHis-tagandalinkerpeptide.TheactivemultimericconformationisstABIlizedbyaninsertedmutationallowinganadditionalCC-bridge.
CrossreactivityHuman
SpecificityBindstohumanTRAILreceptors.
BIOLOGicalActivityInducesapoptosisatconcentrationsof>1ng/ml.Note:Doesnotrequireacross-linkingenhancerforitspotentbiologicalactivity.Showssuperioractivityonhuman celllinesthatrequireextensivecross-linkingofTRAIL-Rsforkilling(e.g.Jurkat).
Purity≥98%(SDS-PAGE)
PurityDetailAffinitypurified.Sterilefiltered.
EndotoxinContent<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">
Concentration0.5mg/ml
FormulationLiquid.In20mMHEPES,pH7.4,150mMNaCl,0.005%Tween20,1%sucrose,1mMDTT.
OtherProductDataInordertoretainfullactivitydonotdilutehigherthantoaconcentrationof0.1mg/ml,prepare20µlaliquotsandstoreat-80°C.Workingdilution:2-100ng/ml.

UniProtlinkP50591:
ShippingandHandling
ShippingDRYICE
ShortTermStorage-20°C
LongTermStorage-80°C
HandlingAdviceAvoidfreeze/thawcycles.
Use/StabilityOncethaweditisrecommendedtoprepareappropriatealiquotsandtostorethemat-80°C.
Stableforatleast1yearafterreceiptwhenstoredat-80°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF