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Adipogen/SUMO3 vinyl sulfone (human) (rec.) (HA)/AG-40T-0386-C050/50 µg
Adipogen/SUMO3 vinyl sulfone (human) (rec.) (HA)/AG-40T-0386-C050/50 µg
商品编号：
AG-40T-0386-C050
品牌：
Adipogen Inc
市场价：
¥8740.00
美元价：
5244.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | SmallUbiquitin-relatedModifier3;HSMT3;SMT3Homolog1;Ubiquitin-likeProteinSMT3B |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanSUMO3vinylsulfone(AccessionNr.P55854)fusedtoaN-terminalHA-tag. |
| Crossreactivity | Human |
| Formulation | Liquid.In50mMHepespH7.0,150mMNaCl,10%glycerol. |
| OtherProductData | Use:Potent,irreversIBLeandspecificinhibitorofSUMO-specificproteases(SENPs).Thisproteininhibitsthehydrolysisofpoly-SUMOchainsonsubstrateproteinsinvitroandthusenhancespoly-SUMOchainaccumulation.TheHA-epitopeallowsforthesensitiveidentificationorpurificationofSENPactivitiessinceitisspecificallyrecognizedbyanti-HAantibodiesoranti-HA-agarose.Adddirectlytoinvitroassayfromthestocksolution.Dependingonconditions,typicalconcentrationstofullyinhibitSENPsinvitroare1-5μM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
SmallUbiquitin-likeModifier3(SUMO3),alsoknownasSMT3A,issynthesizedasa103aminoacid(aa),propeptidewithapredicted11.5kDa.SUMO3containsatwoaaC-terminalprosegment.HumanSUMO3shares83%sequenceidentitywithmouseSUMO3.SUMO3alsohashighaasequencehomologytoSUMO2andSUMO4,87%and75%,respectively.SUMO3sharesonly47%sequenceidentitywithSUMO1.SUMOsareafamilyofsmall,relatedproteinsthatcanbeenzymaticallyattachedtoatargetproteinbyapost-translationalmodificationprocesstermedSUMOylation.AllSUMOproteinsshareaconservedubiquitindomainandaC-terminaldiglycinecleavage/attachmentsite.Followingprosegmentcleavage,theC-terminalglycineresidueofSUMO3isenzymaticallyattachedtoalysineresidueonatargetprotein.Inhumans,SUMO3isconjugatedtoavarietyofmoleculesinthepresenceoftheSAE1/UBA2SUMO-activating(E1)enzymeandtheUBE2I/Ubc9SUMO-conjugating(E2)enzyme.Inyeast,theSUMO-activating(E1)enzymeisAos1/Uba2p.BecauseofthehighlevelofsequencehomologymoststudiesreporteffectsofSUMO2/3.Forexample,additionofSUMO2/3wasshowntomodulatethefunctionofARHGAP21,aRhoGAPproteinknowntobeinvolvedincellmigration.OtherreportsindicatethattheconjugationbySUMO2/3,butnotSUMO1,mayrepresentanimportantmechanismtoprotectneuronsduringepisodesofcerebralischemia.However,studiessuggestthatSUMO2/3expressionisregulatedinanisoform-specificmannersinceoxidativestressdownregulatedthetranscriptionofSUMO3,butnotSUMO2.SUMOylationcanoccurwithouttherequirementofaspecificE3ligaseactivity,whereSUMOistransferreddirectlyfromUbcH9tospecificsubstrates.SUMOylatedsubstratesareprimarilylocalizedtothenucleus(RanGAP-1,RANBP2,PML,p53,Sp100,HIPK2)buttherearealsocytosolicsubstrates(IκBα,GLUT1,GLUT4).SUMOmodificationhasbeenimplicatedinfunctionssuchasnucleartransport,chromosomesegregation,transcriptionalregulation,cancerandproteinstability.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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