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Adipogen/SUMO2 (K11R Mutant) (human) (rec.)/AG-40T-0380-C250/250 µg
Adipogen/SUMO2 (K11R Mutant) (human) (rec.)/AG-40T-0380-C250/250 µg
商品编号：
AG-40T-0380-C250
品牌：
Adipogen Inc
市场价：
¥6340.00
美元价：
3804.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | SmallUbiquitin-relatedModifier2;HSMT3;SMT3Homolog2;Sentrin-2;Ubiquitin-likeProteinSMT3A |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanSUMO2K11Rmutant(AccessionNr.P61956). |
| Crossreactivity | Human |
| Formulation | Liquid.InHEPES,NaCl,DTTandGlycerol. |
| OtherProductData | Use:IdealforinvestigatingSUMOchainlinkages.PreventsthemodificationofK11withinSUMOand/orpoly-SUMOchains.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof10-50µM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
SmallUbiquitin-likeModifier2(SUMO2),alsoknownasSentrin2andSMT3Bissynthesizedasa95aminoacid(aa),propeptidewithapredicted11kDa.SUMO2containsatwoaaC-terminalprosegmentandan18aaN-terminalproteininteractingregionbetweenaa33-50.HumanSUMO2shares100%aasequenceidentitywithmouseSUMO2.SUMO2alsohasveryhighaasequenceidentitywithSUMO3andSUMO4,86%and85%,respectively.SUMO2sharesonly44%aasequenceidentitywithSUMO1.SUMOsareafamilyofsmall,relatedproteinsthatcanbeenzymaticallyattachedtoatargetproteinbyapost-translationalmodificationprocesstermedSUMOylation.AllSUMOproteinsshareaconservedubiquitindomainandaC-terminaldiglycinecleavage/attachmentsite.Followingprosegmentcleavage,theC-terminalglycineresidueofSUMO2isenzymaticallyattachedtoalysineresidueonatargetprotein.Inhumans,SUMO2isconjugatedtoavarietyofmoleculesinthepresenceoftheSAE1/UBA2SUMO-activating(E1)enzymeandtheUBE2I/Ubc9SUMO-conjugating(E2)enzyme.Inyeast,theSUMO-activating(E1)enzymeisAos1/Uba2p.BecauseofthehighlevelofaasequenceidentitymoststudiesreporteffectsofSUMO2/3.Forexample,post-translationaladditionofSUMO2/3wasshowntomodulatethefunctionofARHGAP21,aRhoGAPproteinknowntobeinvolvedincellmigration.OtherreportsindicatethattheSUMOylationwithSUMO2/3,butnotSUMO1,mayrepresentanimportantmechanismtoprotectneuronsduringepisodesofcerebralischemia.However,studiessuggestthatSUMO2/3expressionisregulatedinanisoform-specificmannersinceoxidativestressdownregulatedthetranscriptionofSUMO3butnotSUMO2.SUMOylationcanoccurwithouttherequirementofaspecificE3ligaseactivity,whereSUMOistransferreddirectlyfromUbcH9tospecificsubstrates.SUMOylatedsubstratesareprimarilylocalizedtothenucleus(RanGAP-1,RANBP2,PML,p53,Sp100,HIPK2),buttherearealsocytosolicsubstrates(IκBα,GLUT1,GLUT4).SUMOmodificationhasbeenimplicatedinfunctionssuchasnucleartransport,chromosomesegregation,transcriptionalregulation,cancerandproteinstability.Mutationoflysine11toargininerendersSUMO2unabletoformpoly-SUMOmultimersandisusefultoinvestigatemono-SUMOylationorcanbeusedtoreducepoly-SUMOchainformation.HumanSUMO2containstheVK11TEsequencewhichallowsfortheformationofpoly-SUMOchains.K11istheconservedlysinethatbecomesmodifiedandisthepointofattachmentfortheC-terminalglycineoftheprecedingSUMO2.ThefunctionofSUMOchainshasnotyetbeenfullyelucidated.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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