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脂肪原/SUMO1（K7R/K17R突变体）（人类）（rec.）/AG-40T-0372-C250/250µg
脂肪原/SUMO1（K7R/K17R突变体）（人类）（rec.）/AG-40T-0372-C250/250µg
商品编号：
AG-40T-0372-C250
品牌：
Adipogen Inc
市场价：
¥6340.00
美元价：
3804.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | SmallUbiquitin-relatedModifier1;GAP-modifyingProtein1;SMT3C,SMT3H3,UBL1;Sentrin;Ubiquitin-homologyDomainProteinPIC1 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanSUMO1K7R/K17Rmutant(AccessionNr.P63165). |
| Crossreactivity | Human |
| Formulation | Liquid.InHEPES,NaClandDTT. |
| OtherProductData | Use:SUMO1chainsdonotreADIlyforminvitro.Mutationoflysines7and17toarginineisusefultoinvestigatemono-SUMOylationrequirementsortoreducepoly-SUMOchainformation.UtilizingthisproteinwillensurethatK7andK17-linkedchainswillnotbeformed.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof10-50µM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
SmallUbiquitin-likeModifier1(SUMO1),alsoknownasSentrin,UBL1,andSMT3C,issynthesizedasa101aminoacid(aa)propeptidewithapredictedmolecularweightof11.5kDa.HumanSUMO1isthemostuniqueofthefouridentifiedSUMOproteinsandsharesonly44%,47%,and41%aasequenceidentitywithSUMO2,SUMO3,andSUMO4,respectively.Incontrast,humanSUMO1shares100%aasequenceidentitywiththemouseortholog.SUMOsareafamilyofsmall,relatedproteinsthatcanbeenzymaticallyattachedtoatargetproteinbyapost-translationalmodificationprocesstermedSUMOylation.AllSUMOproteinsshareaconservedubiquitindomainandaC-terminaldiglycinecleavage/attachmentsite.FollowingcleavageofafouraaC-terminalprosegment,theC-terminalglycineresidueofSUMO1isenzymaticallyattachedtoalysineresidueonatargetprotein.Inhumans,SUMO1isconjugatedtoavarietyofmoleculesinthepresenceoftheSAE1/UBA2SUMO-activating(E1)enzymeandtheUBE2I/Ubc9SUMO-conjugating(E2)enzyme.Inyeast,theSUMO-activating(E1)enzymeisAos1/Uba2p.SUMOylationcanoccurwithouttherequirementofaspecificSUMOligase(E3),whereSUMO1istransferreddirectlyfromUBE2I/Ubc9tospecificsubstrates.InAlzheimer"sdiseasemodelsSUMO1hasbeenshowntoinfluencethegenerationofamyloid-βpeptidebypromotingtheaccumulationofBACE-1.CovalentmodificationofPTENbySUMO1isthoughttoregulatetumOrigenesisbyretainingPTENattheplasmamembrane,aneffectthatsuppressesPI3-Kinase/Akt-dependenttumorgrowth.HumanSUMO-1doesnotcontaintheexactψκXEconsensussequencefoundinSUMO-2andSUMO-3.Withinthismotifψrepresentsalargehydrophobicaminoacid(I,L,orV),Kisthelysinethatbecomesmodified,XisanyresidueandEisglutamicacid.ManyknownSUMO-1conjugationsitesoccurwithinthisconsensussequence,butSUMOylationalsooccursonlysineresidueslocatedwithinnon-consensusregions.SUMO-1hasbeenshowntoformchainsinvitroandinvivobutoftenthelinkageisuncharacterized,andthefunctionofSUMOchainshasnotyetbeenfullyelucidated.SUMO-1multimerizationinvitrohasbeenshowntooccurpredominantlyvialysinesK7,K16andK17.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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