Adipogen/STAM-1 (human) (rec.)/AG-40T-0358-C050/50 µg
商品编号：
AG-40T-0358-C050
品牌：
Adipogen Inc
市场价：
¥5360.00
美元价：
3216.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | SignalTransducingAdapterMolecule1 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | Full-lengthhumanSTAM-1(AccessionNr.Q92783). |
| Crossreactivity | Human |
| Formulation | Liquid.In50mMHEPESpH8.0,200mMNaCl,2mMDTT,2mMEDTA. |
| OtherProductData | Use:HasnointrinsicdeubiquitinaseactivitybutisusefulinstimulatingtheinvitroactivityoftheJAMM-classdeubiquitinaseAMSH.ReactionconditionsforstimulationofAMSHwillneedtobeoptimizedforeachspecificapplication.BindsAMSHproteinwithKd=~7µM.Ininvitroassayscontaining200nMAMSH,a~10-foldincreaseintherateofhydrolysisofK63-linkeddiubiquitinFRETsubstratewasachievedupontheadditionofSTAM.Half-maximalincreaseoccurredat0.4µMSTAM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
SignalTransducingAdaptorMolecule-1(STAM-1)isamembertheSTAMfamilyofadaptormolecules.Thisubiquitouslyexpressedproteinis540aminoacids(aa)inlengthwithapredictedmolecularweightof59.18kDa.HumanSTAM-1shares91%and92%aasequenceidentitywiththeratandmouseorthologs,respectively.ItcontainsmultipledomainsincludingaVHSdomain(aa16-143)andaubiquitin-interactingmotif(aa171-190),bothofwhichbindubiquitinatedproteins,aSH3domain(aa210-269)thatassociateswiththezincmetalloproteaseSTAMBPandanITAMdomain(aa370-387),whichcontainsaHrs-bindingsiteandinteractswithJanuskinases(Jaks).STAM-1isinvolvedindownstreamsignalingstimulatedbycytokinesandgrowthfactors.ItistyrosinephosphorylatedbyJaksinresponsetoavarietyofcytokinesincludingIL-2,IL-3,IL-4,IL-7,GM-CSF,EGFandPDGF,andhasbeenshowntoinduceDNAsynthesisandMYCexpression.Additionally,STAM-1hasbeenshowntoregulateCXCR4signalingandappearstobeimportantforTcelldevelopmentandsurvival.Besidesitsroleinsignaltransduction,STAM-1mayalsobeimportantfortheregulationofendocyticmembranetrafficking.ItassociateswithHrstoformtheESCRT-0complex,whichbindstoubiquitinatedmembraneproteinsonearlyendosomesanddirectsthemtotheESCRT-1complexforlysosomaldegradation.STAM-1hasalsobeenshowntointeractwithcoatproteinIIcomplexesandfunctionintraffickingvesiclesfromtheendoplasmicreticulumtothegolgiapparatus.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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