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Adipogen/SENP2 (catalytic domain) (human) (rec.) (His)/AG-40T-0356-C050/50 µg
Adipogen/SENP2 (catalytic domain) (human) (rec.) (His)/AG-40T-0356-C050/50 µg
商品编号：
AG-40T-0356-C050
品牌：
Adipogen Inc
市场价：
¥3540.00
美元价：
2124.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Sentrin-specificProtease2;Sentrin/SUMO-specificProteaseSENP2;Axam2;SMT3-specificIsopeptidase2 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanSENP2(catalyticdomainaa368-593)(AccessionNr.Q9HC62)fusedtoaN-terminalHis-tag. |
| Crossreactivity | Human |
| MW | ~29kDa |
| Purity | ≥95%(SDS-PAGE) |
| Formulation | Liquid.In50mMHEPESpH8,100mMNaCl,10%glycerol,1mMTCEP. |
| OtherProductData | Use:SUMO-specificdeconjugatingenzyme.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof50-500nM.15minutepre-incubationwith10mMDTTisrecommendedtoachievemaximumactivity. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
SUMO1/Sentrin/SMT3SpecificPeptidase2(SENP2)isamemberoftheSENPfamilyofproteases.SENPsareagroupofcysteine-typepeptidasesthatcatalyzetwoessentialfunctionsintheSUMOpathways:processingoffull-lengthsmallubiquitin-relatedmodifiers(SUMOs)totheirmatureformsanddeconjugationofSUMOsfromSUMOylatedproteins.SENP2is589aminoacids(aa)inlengthwithapredictedmolecularweightof67.9kDa.HumanSENP2shares88%and87%aasequenceidentitywiththemouseandratorthologs,respectively.MammalianSENPsshareaconservedC-terminalcatalyticdomainwhiletheN-terminaldomainshavenosignificantsimilarity.TheN-terminaldomainofSENP2containsanuclearlocalizationsignalandaCRM1-dependentnuclearexportsignalallowingSENP2toshuttlebetweenthenucleusandcytoplasm.Inthenucleus,SENP2associateswithNup153,anucleoporinthatislocatedonthenucleoplasmicsideofthenuclearporecomplex.ItisthoughtthatSENP2functionsareregulatedbyitsassociationwiththenuclearporecomplexandnucleocytoplasmicshuttling.SENP2hasbeenshowntodeSUMOylatemultipleproteinsincludingC/EBPβ,RORα/NR1F1,IRF3,MEF2AandNEMO.Consequently,SENP2isthoughttobecriticalfortheregulationofvariouscellularprocessessuchasADIpogenesis,immuneresponsesandcancercellgrowth.Additionally,SENP2deSUMOylatesMDM2,allowingMDM2tobindandubiquitinatep53.SENP2-mediatedregulationofMDM2appearstobecriticalforthedevelopmentofthetrophoblastduringembryogenesisandmaintenanceofthegenomeduringstressresponses.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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