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Adipogen/Pro-SUMO3 (human) (rec.)/AG-40T-0342-C500/500 µg
Adipogen/Pro-SUMO3 (human) (rec.)/AG-40T-0342-C500/500 µg
商品编号：
AG-40T-0342-C500
品牌：
Adipogen Inc
市场价：
¥6340.00
美元价：
3804.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | SmallUbiquitin-relatedModifier3;HSMT3;SMT3Homolog1;Ubiquitin-likeProteinSMT3B |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanPro-SUMO3(AccessionNr.P55854). |
| Crossreactivity | Human |
| Formulation | Liquid.In50mMHEPESpH8.0,150mMNaCl,1mMDTT. |
| OtherProductData | Use:CanbeusedasanegativecontrolinSUMOylationreactionsorasasubstrateforSENPs.Typicalinvitroconcentrationsare10-50μMdependingonconditions. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
SmallUbiquitin-likeModifier3(SUMO3),alsoknownasSMT3A,issynthesizedasa103aminoacid(aa),propeptidewithapredicted11.5kDa.SUMO3containsatwoaaC-terminalprosegment.HumanSUMO3shares83%sequenceidentitywithmouseSUMO3.SUMO3alsohashighaasequencehomologytoSUMO2andSUMO4,87%and75%,respectively.SUMO3sharesonly47%sequenceidentitywithSUMO1.SUMOsareafamilyofsmall,relatedproteinsthatcanbeenzymaticallyattachedtoatargetproteinbyapost-translationalmodificationprocesstermedSUMOylation.AllSUMOproteinsshareaconservedubiquitindomainandaC-terminaldiglycinecleavage/attachmentsite.Followingprosegmentcleavage,theC-terminalglycineresidueofSUMO3isenzymaticallyattachedtoalysineresidueonatargetprotein.Inhumans,SUMO3isconjugatedtoavarietyofmoleculesinthepresenceoftheSAE1/UBA2SUMO-activating(E1)enzymeandtheUBE2I/Ubc9SUMO-conjugating(E2)enzyme.Inyeast,theSUMO-activating(E1)enzymeisAos1/Uba2p.BecauseofthehighlevelofsequencehomologymoststudiesreporteffectsofSUMO2/3.Forexample,additionofSUMO2/3wasshowntomodulatethefunctionofARHGAP21,aRhoGAPproteinknowntobeinvolvedincellmigration.OtherreportsindicatethattheconjugationbySUMO2/3,butnotSUMO1,mayrepresentanimportantmechanismtoprotectneuronsduringepisodesofcerebralischemia.However,studiessuggestthatSUMO2/3expressionisregulatedinanisoform-specificmannersinceoxidativestressdownregulatedthetranscriptionofSUMO3,butnotSUMO2.AllSUMOisoformsaretranslatedwithadditionalC-terminalresiduesthathavetoberemovedtogeneratetheactiveprotein.Pro-SUMO-3(103aa)istheinactiveprecursorofSUMO-3(92aa)andisprocessedattheC-terminusbySUMO-3specificproteases(SENPs).TheresultingSUMO-3proteinhastheconservedC-terminalGly-Glyresiduesthatfunctioninactivationandconjugationreactions.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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