脂肪原/聚SUMO2野生型链（2-8）（人类）（记录）/AG-40T-0321-C025/25µg
商品编号：
AG-40T-0321-C025
品牌：
Adipogen Inc
市场价：
¥5160.00
美元价：
3096.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | SmallUbiquitin-relatedModifier2;HSMT3;SMT3Homolog2;Sentrin-2;Ubiquitin-likeProteinSMT3A |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | 2-8humanSUMO2(AccessionNr.P0CG47)covalentlylinkedthroughanisopeptidebondatK11residueofoneSUMO2moleculeandtheC-terminalglycineresidueofanotherSUMO2molecule. |
| Crossreactivity | Human |
| Purity | ≥95%(SDS-PAGE) |
| Formulation | Liquid.In50mMHepespH8.0,100mMNaCl,1mMDTT. |
| OtherProductData | Use:Formedenzymaticallywithwild-typehumanrecombinantSUMO-2linkedvialysine11whichisthepointofattachmentfortheC-terminalglycineoftheprecedingSUMO-2.Mono-SUMO-2hasbeenremovedfromthechainmixture.IdealforinvestigatingSUMO-bindingproteinsandassubstratesforSUMO-specificproteases.Reactionconditionswillneedtobeoptimizedforeachspecificapplication. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
SmallUbiquitin-likeModifier2(SUMO2),alsoknownasSentrin2andSMT3Bissynthesizedasa95aminoacid(aa),propeptidewithapredicted11kDa.SUMO2containsatwoaaC-terminalprosegmentandan18aaN-terminalproteininteractingregionbetweenaa33-50.HumanSUMO2shares100%aasequenceidentitywithmouseSUMO2.Di-SUMO2representstwowild-typerecombinanthumanSUMO2moleculeslinkedviaLys11,whichisthepointofattachmentfortheC-terminalglycineresidueoftheprecedingSUMO2.Di-SUMO2canbeusedasasubstrateforSUMO-specificisopeptidases(SENPs)andDeSUMOylatingIsopeptidase1thatcleavetheisopeptidelinkagebetweentwoSUMO2molecules.ItcanalsobeusedtoinvestigatemechanismsofbindingandrecognitionbySUMO-activating(E1)enzymes,SUMO-conjugating(E2)enzymes,SUMOligases(E3s)andotherproteinsthatcontainSUMObindingdomains.SUMOsareafamilyofsmall,relatedproteinsthatcanbeenzymaticallyattachedtoatargetproteinbyapost-translationalmodificationprocesstermedSUMOylation.UnlikeSUMO1whichisusuallyconjugatedtoproteinsasamonomer,SUMO2andSUMO3formhighmolecularweightpolymersonproteins.AllSUMOproteinsshareaconservedubiquitindomainandaC-terminaldiglycinecleavage/attachmentsite.Followingprosegmentcleavage,theC-terminalglycineresidueofSUMO2isenzymaticallyattachedtoalysineresidueonatargetprotein.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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