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Adipogen/PLpro (SARS Coronavirus) (rec.) (His)/SBB-DE0024-C050/50 µg
Adipogen/PLpro (SARS Coronavirus) (rec.) (His)/SBB-DE0024-C050/50 µg
商品编号：
SBB-DE0024-C050
品牌：
Adipogen Inc
市场价：
¥3320.00
美元价：
1992.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Papain-likeProteinase;SARSCoronavirusMainProteinase;Non-structuralProtein3;PL2-PRO;Nsp3 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | PLpro(Papain-likeProtease)(aa1540-1841)(AccessionNr.P0C6U8)isfusedattheN-terminustoaHis-tag. |
| Crossreactivity | Human |
| Application | PLproisabletohydrolyzebothISG15-Rhodamine110ordi-ubiquitin/tetra-ubiquitinsubstrates,butisveryinefficientwhenprocessingmono-Ubconjugatesorsyntheticpeptidesubstrates.Typicalworkingconcentrationrangeis1-10nM. |
| MW | ~37kDa |
| Purity | ≥95%(SDS-PAGE) |
| Concentration | Lotdependent. |
| AccessionNumber | P0C6U8 |
| Formulation | Liquid.In50mMHEPESpH7.5,100mMsodiumchloride,1mMTCEP. |
| OtherProductData | ClickhereforaTypicalLot-specificProductDatasheetfromtheOriginalManufacturer Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbySouthBayBio. |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -80°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Thesevereacuterespiratorysyndromecoronaviruspapain-likeprotease(SARS-CoVPLpro)isinvolvedintheprocessingoftheviralpolyprotein.Proteolyticprocessingofthecoronavirusreplicasepoly-proteinisessentialforgeneratingafunctionalvirusreplicationcomplex.PLpropossessesbothdeubiquitinatingordeISGylatingactivityandcanprocessLys48andLys63linkedpolyubiquitinchains(freechainsorfromcellularsubstrates).Itworksinconcerttogetherwithnsp4intheassemblyofvirally-inducedcytoplasmicdouble-membranevesiclesnecessaryforviralreplication.ItstronglyantagonizestheinnateimmuneinductionoftypeIinterferonbyblockingthephosphorylation,dimerizationandthereforethenucleartranslocationofhostIRF3.Inaddition,itpreventsalsohostNF-κ-Bsignaling.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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