当前位置：
首页
>
产品中心 >
Other_recombinant_protein >
Adipogen/PINK1 (Tribolium castaneum) (rec.) (MBP) (His)/AG-40T-0556-C100/100 µg
Adipogen/PINK1 (Tribolium castaneum) (rec.) (MBP) (His)/AG-40T-0556-C100/100 µg
商品编号：
AG-40T-0556-C100
品牌：
Adipogen Inc
市场价：
¥10700.00
美元价：
6420.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | PTEN-inducedPutativeKinase1;Serine/Threonine-proteinKinasePINK1,Mitochondrial;PARK6;ParkinsonDisease(AutosomalRecessive)6;BRPK;EC2.7.11.1;FLJ27236 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | PINK1(Triboliumcastaneum)(AccessionNr.XP_968367.1)fusedtoaN-terminalMBPandHis-tag. |
| Crossreactivity | Human |
| MW | ~108kDa |
| Purity | ≥90%(SDS-PAGE) |
| Formulation | Liquid.In20mMHEPESpH7.6,50mMNaCl,10%(v/v)Glycerol,1mMTCEP. |
| OtherProductData | Use:WerecommendaninitialPINK1concentrationof0.5-2μMforthephosphorylationofrecombinantParkin,UbiquitinorPolyubiquitinchains.Reactionconditionswillneedtobeoptimizedforeachspecificapplication. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Serine/ThreoninekinasePINK1(PTEN-inducedputativekinaseprotein1)playsacriticalroleinpreventingmitochondrialdysfunctionduringcellularstress.PINK1istranslatedinthecytosol,thentranslocatedtotheoutermitochondrialmembranewhereitisrapidlycleavedanddegradedasapartofnormalmitochondrialfunction.Indamaged(depolarized)mitochondriaPINK1becomesstabilizedandaccumulates,resultinginthesubsequentphosphorylationofnumerousproteinsonthemitochondrialsurfaceincludingMfn2.UltimatelyPARK2(E3UbiquitinLigaseParkin)isrecruitedtothedamagedmitochondriawhereitisactivatedbyPINK-mediatedphosphorylationofPARK2atserine65,andPARK2interactionwithphosphorylatedUbiquitin(alsophosphorylatedbyPINKonserine65).Thissignalingcascadeiscriticalforclearingthedamagedmitochondriaviaselectiveautophagy(mitophagy)bymediatingactivationandtranslocationofPARK2.
RecombinanthumanPINK1isnotactiveinvitro,whilethisproteinproducedfromtheRedFlourBeetle(Triboliumcastaneum)effectivelyphosphorylatesrecombinantParkin,mono-Ubiquitin,andpoly-Ubiquitinchains.ItspecificallyphosphorylatesbothParkinandUbiquitinatserine65.
RecombinanthumanPINK1isnotactiveinvitro,whilethisproteinproducedfromtheRedFlourBeetle(Triboliumcastaneum)effectivelyphosphorylatesrecombinantParkin,mono-Ubiquitin,andpoly-Ubiquitinchains.ItspecificallyphosphorylatesbothParkinandUbiquitinatserine65.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
