Adipogen/Parkin (human) (rec.)/AG-40T-0552-C025/25 µg
商品编号：
AG-40T-0552-C025
品牌：
Adipogen Inc
市场价：
¥11340.00
美元价：
6804.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | E3Ubiquitin-proteinLigaseParkin;PARK2;ParkinsonJuvenileDiseaseProtein2;AR-JP;E3UbiquitinLigase;LPRS2;ParkinsonDiseaseProtein2;PDJ;PRKN |
| ProductType | Protein |
| Properties | |
| Source/Host | Sf21cells |
| Sequence | HumanParkin(AccessionNr.O60260).Thisproteinisuntagged. |
| Crossreactivity | Human |
| MW | ~52kDa |
| Purity | ≥90%(SDS-PAGE) |
| Formulation | Liquid.In25mMTris-HClpH8.5,200mMNaCl,0.03%Brij35,10%(v/v)Glycerol,5mMTCEP. |
| OtherProductData | Use:Assupplied,ParkinhasnegligIBLeE3ligaseactivityasdeterminedbythelackofautoubiquitinationinaninvitroassay.ParkinligaseactivityisgreatlyenhancedbyphosphorylationwithPINK1kinaseorbytheadditionoflowconcentrationsofphosphorylatedUbiquitin.Reactionconditionswillneedtobeoptimizedforeachspecificapplication. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
TheE3UbiquitinligaseParkin(encodedbythePARK2gene)isanessentialpartofthecellularmachinerythatparticipatesintheremovalofdamagedmitochondria.MutationsinPARK2areknowntocauseaformofParkinson"sdiseaseknownasautosomalrecessivejuvenileParkinson"sdisease(AR-JP)andthemechanismsbywhichdefectiveParkinligasecontributestothedopaminergiccelldeathinthisdiseaseisanareaofintenseinvestigation.ReportedsubstratesforParkinincludeBCL2,GPR37,MIRO1,MFN1,MFN2,TOMM20,USP30andmanyothers.Parkin(anRBR-classUbiquitinligase)structureshaverecentlybeenreportedbymultiplegroupsandrevealthattheligaseisfoldeduponitselftoproduceanauto-inhibitedstate.Theauto-inhibitionisrelievedbyinteractionswithPINK1kinase(whichcanphosphorylatebothParkinandUbiquitinatserineresiduenumber65)andpS65phospho-Ubiquitinbymechanismsthatareunderinvestigation.Invitro,ParkinmaybeactivatedbytreatmentwithrecombinantPINK1,oradditionoflowconcentrationsofpS65-phosphoubiquitin.Parkinhasbeenreportedtogeneratepoly-UbiquitinchainsinK6,K11,K48,andK63linkagesbothinvitroandinvivo.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
