Adipogen/p53 (human) (rec.)/AG-40T-0312-C020/20 µg
商品编号：
AG-40T-0312-C020
品牌：
Adipogen Inc
市场价：
¥8280.00
美元价：
4968.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CellularTumorAntigenp53;TumorSuppressorp53,TP53 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | Humanp53(AccessionNr.P04637). |
| Crossreactivity | Human |
| Formulation | Liquid.In50mMHEPESpH7.5,450mMNaCl,10%Glycerol(v/v),30µMZnCl2. |
| OtherProductData | Use:Idealforuseasacontrolsubstrateforinvitroubiquitinconjugation.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof0.5-2.5µM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
p53iswellknownforitskeyroleasatumorsuppressorprotein.Itis393aminoacids(aa)inlengthwithapredictedmolecularweightof44kDa.Itbelongstothep53familythatalsoincludesp63andp73.Structurally,p53ischaracterizedbyanN-terminaltransactivationdomain,centralDNA-bindingandoligomerizationdomains,andaC-terminalregulatorydomain.Itisthoughttoexistasahomotetramer,anditexhibitsapproximately72%and76%aaidentitywithitsmouseandratorthologs,respectively.Mutationsinthep53geneareoneofthemostfrequentgenomiceventsaccompanyingoncogenictransformation.p53respondstosignalssuchasDNAdamageorcellstressprimarilythroughitsactionsasatranscriptionfactor.AmongitsgenetargetsarearangefactorsthatpromoteDNArepairmechanismsorcancer,includingcellcycleregulatoryproteinsandmemberstheBcl-2family.Becauseofitscriticalroleingenomichomeostasis,p53activitiesaretightlyregulatedbyanetworkofprotein-proteininteractions,microRNAs,andarangeofpost-translationalmodifications,includingphosphorylation,acetylation,methylationandubiquitination.Thestabilityofp53isregulatedviatheubiquitin-proteasomepathway(UPP).MDM2isanoncogenicubiquitinE3ligasethatubiquitinatesp53,inhibitsitstranscriptionalactivityandpromotesitsdegradation.OtherE3ligasesthatpromotetheproteasome-mediateddegradationofp53includePirh2,COP1andp300.USP7(HAUSP)stabilizesp53bydeubiquitinationandinducesp53-dependentcellgrowthrepressionandcancer.Additionalfactorssuchasp14ARFandMdmXalsomodulatep53functionviatheUPP.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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