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Adipogen/p300 (human) (rec.) (His) (highly active)/AG-40T-0023-C002/2 µg
Adipogen/p300 (human) (rec.) (His) (highly active)/AG-40T-0023-C002/2 µg
商品编号：
AG-40T-0023-C002
品牌：
Adipogen Inc
市场价：
¥4400.00
美元价：
2640.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | HistoneAcetyltransferasep300;p300HAT;E1A-associatedProteinp300 |
| ProductType | Protein |
| Properties | |
| Source/Host | Sf21cells |
| Sequence | Humanp300isfusedtoaHis-tag. |
| Crossreactivity | Human |
| BIOLOGicalActivity | 100ngrequiredforacetylationassay. |
| Purity | ≥95%(SDS-PAGE) |
| Concentration | Lotdependent(0.2-1.5mg/ml) |
| Formulation | Liquid.In50mMTRIS-HCl,pH7.5,containing100mMsodiumchloride,0.2%NP-40,50mMimidazoleand10%glycerol. |
| OtherProductData | UniProtIDQ09472: p300(human) |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-80°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
p300functionsashistoneacetyltransferaseandregulatestranscriptionviachromatinremodeling.Itacetylatesallfourcorehistonesinnucleosomes,whilethehistoneacetylationgivesanepigenetictagfortranscriptionalactivation.p300mediatescAMP-generegulationbybindingspecificallytophosphorylatedCREBprotein.Itfunctionsasaacetyltransferasefornonhistonetargets.Itacetylates"Lys-131"ofALX1andactsasitscoactivatorinthepresenceofCREBBP.p300acetylatessirtuin2(SIRT2)andisproposedtoindirectlyincreasethetranscriptionalactivityofTP53throughacetylationandsubsequentattenuationofSIRT2deacetylasefunction.ItacetylatesHDAC1leADIngtoitsinactivationandmodulationoftranscription.ItpromotescardiacmyocyteenlargementandbindstoandmaybeinvolvedinthetransformingcapacityoftheadenovirusE1Aprotein.IncaseofHIV-1infection,itisrecruitedbytheviralproteinTat.p300regulatesTat"stransactivatingactivityandmayhelpinducingchromatinremodelingofproviralgenes.ItacetylatesFOXO1andenhancesitstranscriptionalactivity.
ProductReferences
- Functionalrelevanceofnovelp300-mediatedlysine314and315acetylationofRelA/p65:C.Buerki,etal.;NucleicAcidsRes.36,1665(2008)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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