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Adipogen/NMNAT3 (human) (rec.) (His) (highly active)/AG-40T-0093-3050/3 x 50 µg
Adipogen/NMNAT3 (human) (rec.) (His) (highly active)/AG-40T-0093-3050/3 x 50 µg
商品编号：
AG-40T-0093-3050
品牌：
Adipogen Inc
市场价：
¥19200.00
美元价：
11520.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NicotinamideMononucleotideAdenylyltransferase3;NMNAdenylyltransferase3;NaMNAdenylyltransferase3;EC2.7.7.18;EC2.7.7.1 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | Humanfull-lengthNMNAT3(aa1-252)isfusedattheN-terminustoaHis-tag. |
| Crossreactivity | Human |
| Application | WellsuitedforthesynthesisofNADanalogsduetolowersubstrateselectivitycomparedtoNMNAT1(human)(rec.)(His)(highlyactive).ForNADsynthesisuseNMNAT1(human)(rec.)(His)(highlyactive)(AG-40T-0092). |
| BIOLOGicalActivity | ≥2U/mgprotein.Oneunitisdefinedastheamountofenzymethatsynthesizes1µmolofNAD+permin. |
| MW | ~27kDa(monomer) |
| Purity | ≥95%(SDS-PAGE) |
| EndotoxinContent | N/A |
| Concentration | 1mg/ml |
| Formulation | Liquid.In50mMTRIS-HCl,pH8.0,containing300mMsodiumchloride,1mMDTTand10%glycerol. |
| OtherProductData | UniProtlinkQ96T66:NMNAT3(human) |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
MitochondrialNMNATisoform.CatalyzestheformationofNAD+fromnicotinamidemononucleotide(NMN)andATP.Canalsousethedeamidatedformofnicotinicacidmononucleotide(NAMN)assubstratewiththesameefficiency.Canusetiazofurinmonophosphateassubstrate.CanalsouseGTPandITPasnucleotidedonors.Alsocatalyzesthereversereaction,i.e.thepyrophosphorolyticcleavageofNAD+.Forthepyrophosphorolyticactivity,mitochondrialNMNATisoformcanuseNAD(+),NADH,NAAD,nicotinicacidadeninedinucleotidephosphate(NHD),nicotinamideguaninedinucleotide(NGD)assubstrates.FailstocleavephosphorylateddinucleotidesNADP+,NADPHandNAADP+.Protectsagainstaxonaldegenerationfollowinginjury.
ProductReferences
- StructuralcharacterizationofahumancytosolicNMN/NaMNadenylyltransferaseandimplicationinhumanNADbiosynthesis:X.Zhang,etal.;J.Biol.Chem.278,13503(2003)
- Subcellularcompartmentationanddifferentialcatalyticpropertiesofthethreehumannicotinamidemononucleotideadenylyltransferaseisoforms:F.Berger,etal.;J.Biol.Chem.280,36334(2005)
- TheNMN/NaMNadenylyltransferase(NMNAT)proteinfamily:C.Lau,etal.;Front.Biosci.14,410(2009)
- Isoform-specifictargetingandinteractiondomainsinhumannicotinamidemononucleotideadenylyltransferases:C.Lau,etal.;J.Biol.Chem.285,18868(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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