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Adipogen/NF-κB (p50) (human) (rec.) (His) (highly active)/AG-40T-0021-C002/2 µg
Adipogen/NF-κB (p50) (human) (rec.) (His) (highly active)/AG-40T-0021-C002/2 µg
商品编号：
AG-40T-0021-C002
品牌：
Adipogen Inc
市场价：
¥6200.00
美元价：
3720.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NuclearFactorNF-κBp50Subunit |
| ProductType | Protein |
| Properties | |
| Source/Host | Sf21cells |
| Sequence | HumanNF-κB(p50)isfusedtoaHis-tag. |
| Crossreactivity | Human |
| BIOLOGicalActivity | ~1ngisrequiredforhighmobilityshiftassay. ~5ngarerequiredforreconstitutedtranscriptionassays. |
| Purity | ≥95%(SDS-PAGE) |
| Concentration | Lotdependent(approx.0.2mg/ml) |
| Formulation | Liquid.In50mMTRIS-HCl,pH7.5,containing100mMsodiumchloride,0.2%NP-40,50-100mMimidazoleand10%glycerol. |
| OtherProductData | UniProtIDP19838: NF-κB(human)(p50subunit) |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-80°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
NF-κBisapleiotropictranscriptionfactorpresentinalmostallcelltypesandistheendpointofaseriesofsignaltransductioneventsthatareinitiatedbyavastarrayofstimulirelatedtomanybiologicalprocessessuchasinflammation,immunity,differentiation,cellgrowth,tumOrigenesisandapoptosis.NF-κBisahomo-orheterodimericcomplexformedbytheRel-likedomain-containingproteinsRELA/p65,RELB,NFKB1/p105,NFKB1/p50,RELandNFKB2/p52.Theheterodimericp65-p50complexisthemostabundantcomplex.ThedimersbindatκBsitesintheDNAoftheirtargetgenesandtheindividualdimershavedistinctpreferencesfordifferentκBsitesthattheycanbindwithdistinguishableaffinityandspecificity.Differentdimercombinationsactastranscriptionalactivatorsorrepressors,respectively.NF-κBcomplexesareheldinthecytoplasminaninactivestatecomplexedwithmembersoftheNF-κBinhibitor(I-κB)family.Inaconventionalactivationpathway,I-κBisphosphorylatedbyI-κBkinases(IKKs)inresponsetodifferentactivators,subsequentlydegradedthusliberatingtheactiveNF-κBcomplexwhichtranslocatestothenucleus.NF-κBheterodimericp65-p50andRelB-p50complexesaretranscriptionalactivators.TheNF-κBp50-p50homodimerisatranscriptionalrepressor,butcanactasatranscriptionalactivatorwhenassociatedwithBCL3.
ProductReferences
- Transcriptionalcoactivationofnuclearfactor-kappaB-dependentgeneexpressionbyp300isregulatedbypoly(ADP)-ribosepolymerase-1:P.O.Hassa,etal.;J.Biol.Chem.278,45145(2003)
- Acetylationofpoly(ADP-ribose)polymerase-1byp300/CREB-bindingproteinregulatescoactivationofNF-kappaB-dependenttranscription:P.O.Hassa,etal.;J.Biol.Chem.280,40450(2005)
- Oxidizedguaninebaselesionsfunctionin8-oxoguanineDNAglycosylase-1-mediatedepigeneticregulationofNuclearFactorκB-drivengeneexpression:L.Pan,etal.;J.Biol.Chem.291,25553(2016)
- OGG1-DNAinteractionsfacilitateNF-κBbindingtoDNAtargets:L.Pan,etal.;Sci.Rep.7,43297(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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