脂肪原/Netrin-1（人类）（记录）/AG-40B-0040-C010/10µg
商品编号：
AG-40B-0040-C010
品牌：
Adipogen Inc
市场价：
¥5000.00
美元价：
3000.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NTN1 |
| ProductType | Protein |
| Properties | |
| Source/Host | HEK293cells |
| Sequence | Humannetrin-1(aa25-604)isfusedattheC-terminustoaFLAG®-tag. |
| Crossreactivity | Human Mouse Rat |
| Specificity | Bindstohuman,mouseandratUNC5B. |
| BIOLOGicalActivity | Inducespluripotentstemcell(iPS)formationandimprovesreprogrammingefficiencyofhumanandmousesomaticcellsbyinhibitingapoptosismediatedbythereceptorsDCCorUNC5B(at150ng/ml).Inducesaxonoutgrowth. |
| MW | ~80kDa(SDS-PAGE) |
| Purity | ≥95%(SDS-PAGE) |
| EndotoxinContent | <0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | 10µgvial:0.1mg/mlafterreconstitution. 100µgvial:1mg/mlafterreconstitution. |
| Reconstitution | Reconstitutewith100μlsteriledistilledwater. |
| Formulation | Lyophilized.ContainsPBSplusproteinstABIlizer.NoBSAincluded.Theproteinstabilizershowsnointerferencewithproteinactivity. |
| OtherProductData | UniProtlinkO95631:Netrin-1(human) |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions. |
| Use/Stability | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Netrin-1controlsguidanceofCNScommissuralaxonsandperipheralmotoraxons.ItsassociationwitheitherDCCorsomeUNC5receptorswillleadtoaxonattractionorrepulsion,respectively.Italsoserveasasurvivalfactorviaitsassociationwithitsreceptorswhichpreventtheinitiationofapoptosis.Netrin-1isalsoInvolvedintumOrigenesisbyregulatingapoptosis.Netrin-1promotesatherosclerosisbyretainingmacrophagesinthearterywall.Netrin-1alsogovernsinducedpluripotentstemcell(iPS)formationandimprovesreprogrammingefficiencyofhumanandmousesomaticcellsbylimitingapoptosismediatedbyNetrin-1receptorsDCCorUNC5b.
ProductReferences
- Netrin-1regulatessomaticcellreprogrammingandpluripotencymaintenance:D.Ozmadenci,etal.;Nat.Commun.6,ID7398(2015)
- Targetingnetrin‐1/DCCinteractionindiffuselargeB‐cellandmantlecelllymphomas:L.Broutier,etal.;EMBOMol.Med.8,96(2016)
- InhibitionofDNAmethylationpromotesbreasttumorsensitivitytonetrin‐1interference:M.Grandin,etal.;EMBOMol.Med.8,863(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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