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Adipogen/NEDD8 vinyl sulfone (human) (rec.)/AG-40T-0302-C025/25 µg
Adipogen/NEDD8 vinyl sulfone (human) (rec.)/AG-40T-0302-C025/25 µg
商品编号：
AG-40T-0302-C025
品牌：
Adipogen Inc
市场价：
¥8740.00
美元价：
5244.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NeuralPrecursorCellExpressedDevelopmentallyDown-RegulatedProtein8;Neddylin;Rub1 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanNEDD8vinylsulfone(AccessionNr.Q15843)fusedtoaFLAG-tag. |
| Crossreactivity | Human |
| Formulation | Liquid.In50mMHepespH6.5,150mMNaCl,150mMsodiumacetate,10%glycerol. |
| OtherProductData | Use:PotentandirreversIBLeinhibitorofNEDD8-specificisopeptidases(likeNEDP1orSENP8).Usefulforinhibitingthehydrolysisofpoly-NEDD8chainsonsubstrateproteinsinvitroandthusenhancespoly-NEDD8chainaccumulation.TheFLAG-epitopeallowsforthesensitiveidentificationorpurificationofNEDD8deconjugatingactivitiessinceitisspecificallyrecognizedbyanti-FLAGantibodiesM1,M2orM5.Adddirectlytoinvitroassayfromthestocksolution.Dependingonconditions,typicalconcentrationstofullyinhibitSENPsinvitroare1-5µM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
NeuralPrecursorCellExpressedDevelopmentallyDownregulatedGene8(NEDD8),alsoknownasRub1,isa6-8kDamemberoftheubiquitinfamilyofproteins.Humanpro-NEDD8is81aminoacids(aa)inlength.Pro-NEDD8containsoneubiquitin-likedomain(aa1-65)anda4-5aaC-terminalpropeptide.CleavageofthepropeptideexposesaC-terminalglycineresiduethatisusedtogenerateaglycine-lysineintermolecularbond.MaturehumanNEDD8shows100%aaidentitytoNEDD8frommouse,ratandcanine.HumanNEDD8isactivatedbyadistinctNEDD8-activating(E1)enzyme,aheterodimericcomplexcomposedofAPPBP1andUBA3subunits.ActivatedNEDD8issubsequentlytransferredtotheUBE2M/Ubc12orUBE2FNEDD8-conjugating(E2)enzymes.Throughaprocesstermedneddylation,theROC1/Rbx1RINGFingerE3ligasetransfersNEDD8tospecificsubstrates.Forexample,transferofNEDD8tothecullinscaffoldactivatesmembersoftheCullin-RINGLigase(CRL)familyofubiquitinligases(E3).CRL-inducedubiquitinationisknowntoregulateproteinsthatareimportantforcellcycleprogressionandcellsurvival.Physiologically,NEDD8playsacriticalregulatoryroleincellproliferationanddysregulationoftheNEDD8pathwayhasbeenassociatedwithseveralcancerpathologies.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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