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Adipogen/NEDD8 E1 (human) (rec.)/AG-40T-0299-C025/25 µg
Adipogen/NEDD8 E1 (human) (rec.)/AG-40T-0299-C025/25 µg
商品编号：
AG-40T-0299-C025
品牌：
Adipogen Inc
市场价：
¥8620.00
美元价：
5172.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NEDD8-activatingEnzymeE1C;Ubiquitin-activatingEnzymeE1C;UBE1C;APPBP1/UBA3 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanNEDD8E1(AccessionNr.APP-BP1|UBA3). |
| Crossreactivity | Human |
| Formulation | Liquid.InHEPESandNaCl. |
| OtherProductData | Use:MemberoftheNEDD8-activating(E1)enzymefamilythatisrequiredforthefirststepoftheenzymaticcascadethatsubsequentlyutilizesaNEDD8-conjugating(E2)enzymeandaNEDD8ligase(E3)toconjugateNEDD8tosubstrateproteins.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof50-200nM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
NEDD8ActivatingEnzyme1(APPBP1/UBA3)isaheterodimericNEDD8-activating(E1)enzymewithapredictedmolecularweightof112kDa.ItisresponsIBLeforthefirststepintheconjugationofNEDD8toproteinsubstrates.TheNEDD8activatingenzymeheterodimeriscomposedofaregulatorysubunit,APPBP1andacatalyticsubunit,ubiquitin-likemodifieractivatingenzyme3(UBA3).HumanAPPBP1isa534aminoacid(aa)proteinwithapredictedmolecularweightof60kDathatisexpressedubiquitouslyinfetaltissuesandintheadultbrain.APPBP1isrequiredforUBA3neddylationactivity,regulatesenzymespecificityandisexpressedastwoisoforms,thefulllengthproteinandasecondisoformwithanalternateN-terminal,aa1-17sequence.APPBP1hasbeenshowntodrivecellcycleprogressionanditsexpressionisincreasedinthehippocampusofAlzheimer"sdiseasebrains.HumanUBA3isa463aaproteinwithapredictedmolecularweightof52kDa.ItisubiquitouslyexpressedandshareshighaasequenceidentitywiththeC-terminaldomainofhumanUBE1.UBA3containsanATP-bindingdomainandanactivesitecysteineresidue,Cys237inhumans,whicharebothcommontoE1enzymes.LikeAPPBP1,twoisoformsofUBA3havebeenidentifiedinhumans,thefulllengthproteinandatruncatedisoform,whichlacksaa8-21.UBA3isrequiredforcellcycleprogressionandhasbeenshowntodownregulatesteroidreceptoractivation.NeddylationanditsassociatedenzymeshavebeenimplicatedintheprogressionofAlzheimer"sdisease,vianeddylationofAPP,andcancerviapost-translationalmodificationofoncogenes.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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