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Adipogen/NEDD8 (human) (rec.) (FITC)/AG-40T-0293F-C050/50 µg
Adipogen/NEDD8 (human) (rec.) (FITC)/AG-40T-0293F-C050/50 µg
商品编号：
AG-40T-0293F-C050
品牌：
Adipogen Inc
市场价：
¥6340.00
美元价：
3804.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NeuralPrecursorCellExpressedDevelopmentallyDown-RegulatedProtein8;Neddylin;Rub1 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanNEDD8(AccessionNr.Q15843)conjugatedtoFITC. |
| Crossreactivity | Human |
| Label/Conjugates | FITC |
| Formulation | Liquid.In20mMHEPESpH8.0. |
| OtherProductData | Use:ModifiedwithfluoresceinviaprimaryaminecouplingisidealasanalternativetorADIolabeledNEDD8.ThisresultsinmultiplefluoresceinatedNEDD8specieswithmodifiedlysinesaswellastheN-terminus.Fluorescein-NEDD8givesastrongsignalintherangeof0.1-1μM,dependingonexactexperimentalconditions.OptimalfluorescenceatpH8.0ismonitoredusingEx494nMandEm520nMwavelengths,respectively. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
NeuralPrecursorCellExpressedDevelopmentallyDownregulatedGene8(NEDD8),alsoknownasRub1,isa6-8kDamemberoftheubiquitinfamilyofproteins.Humanpro-NEDD8is81aminoacids(aa)inlength.Pro-NEDD8containsoneubiquitin-likedomain(aa1-65)anda4-5aaC-terminalpropeptide.CleavageofthepropeptideexposesaC-terminalglycineresiduethatisusedtogenerateaglycine-lysineintermolecularbond.MaturehumanNEDD8shows100%aaidentitytoNEDD8frommouse,ratandcanine.HumanNEDD8isactivatedbyadistinctNEDD8-activating(E1)enzyme,aheterodimericcomplexcomposedofAPPBP1andUBA3subunits.ActivatedNEDD8issubsequentlytransferredtotheUBE2M/Ubc12orUBE2FNEDD8-conjugating(E2)enzymes.Throughaprocesstermedneddylation,theROC1/Rbx1RINGFingerE3ligasetransfersNEDD8tospecificsubstrates.Forexample,transferofNEDD8tothecullinscaffoldactivatesmembersoftheCullin-RINGLigase(CRL)familyofubiquitinligases(E3).CRL-inducedubiquitinationisknowntoregulateproteinsthatareimportantforcellcycleprogressionandcellsurvival.Physiologically,NEDD8playsacriticalregulatoryroleincellproliferationanddysregulationoftheNEDD8pathwayhasbeenassociatedwithseveralcancerpathologies.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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