脂肪原/Nck1（人类）（推荐）/YIF-LF-P0301/0.2毫克
商品编号：
YIF-LF-P0301
品牌：
Adipogen Inc
市场价：
¥7000.00
美元价：
4200.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NCK;NCK1;Nck-1;NCKAdaptorProtein1;CytoplasmicProteinNCK1;SH2/SH3AdaptorProteinNCK-α |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Crossreactivity | Human |
| Purity | ≥95%(SDS-PAGE) |
| Formulation | Lyophilizedfrom50mMNaH2PO4,pH8.0,300mMNaCl,170mMimidazole. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Afterreconstitution,storeat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
NCK1isoneoftheadaptorproteinswhichmediatespecificprotein-proteininteractionsinsignalingprocesses.AdaptorproteinsusuallycontainseveraldomainslikeSH2(Srchomology2)andSH3whichallowspecificinteractionswithotherspecificproteins.NCK1andNCK2showinghighsequenceidentity(68%)havethreeSH3domainsandaC-terminalSH2domain.BothofthembindreceptortyrosinekinasessuchasPDGFRandothertyrosinephosphorylatedproteinsviatheirSH2domains.VariousmoleculeswhichinteractwithSHdomainsofNckandregulatesignalingprocessofactinCytoskeletonreorganizationhavebeenidentified.Ncksarethoughttohaveimportantfunctionsinthedevelopmentofmesodermalstructuresduringembryogenesis,linkedtoaroleincellmovementandcytoskeletalreorganization.NckalsohaveafunctioninmodulatingmRNAtranslationatthelevelofinitiationbyinteractingeukayoticinitiationfactor2(eIF2).Underthestressedconditions,proteinsynthesisisreducedbyinhibitingtheactivityofeIF2throughthephosphorylation,transientlyinhibitingrecyclingofeIF2intoitsactiveform.
ProductReferences
1)LatreilleMandLaroseL.,(2006)JBiolChem281:26633-26644.(General)
2)FreseSetal.,(2006)JBiolChem281:18236-18245.(General)
3)BladtFetal.,(2003)MolCellBiol23:4586-4597.(General)
2)FreseSetal.,(2006)JBiolChem281:18236-18245.(General)
3)BladtFetal.,(2003)MolCellBiol23:4586-4597.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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