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Adipogen/MDM2 (human) (rec.) (GST)/AG-40T-0290-C050/50 µg
Adipogen/MDM2 (human) (rec.) (GST)/AG-40T-0290-C050/50 µg
商品编号：
AG-40T-0290-C050
品牌：
Adipogen Inc
市场价：
¥9060.00
美元价：
5436.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | E3Ubiquitin-proteinLigaseMdm2;DoubleMinute2Protein;HDM2 |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | HumanMDM2(AccessionNr.Q00987-11)fusedtoaN-terminalGST-tag. |
| Crossreactivity | Human |
| Formulation | Liquid.InHEPES,NaCl,GlycerolandTCEP. |
| OtherProductData | Use:RINGfingerubiquitinligase(E3)thatfunctionsdownstreamofaubiquitin-activating(E1)enzymeandaubiquitin-conjugating(E2)enzymetoconjugateubiquitintosubstrateproteins.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof0.5-4µM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
DoubleMinute2Protein(Mdm2,alsoknownasHdm2)isaRING-fingerubiquitinE3ligasethatactsasamajorregulatorofthetumorsuppressorp53.Mdm2inhibitsp53-mediatedcellcyclearrestandCancerbybindingitstranscriptionalactivationdomain.TheE3ligaseactivityisconfinedtotheC-terminaldomainofMdm2andisresponsIBLefortheubiquitinationandsubsequentproteasomaldegradationofp53.AlthoughtheisolatedRINGdomainiscapableofp53ubiquitination,otherregionsoftheproteinincludingacentralacidicdomainarealsocrucialforfullE3ligaseactivity.Mdm2alsoregulatesitsownintracellularlevelsbyauto-ubiquitination,andcanbeSUMOylatedwhichdecreasesautoubiquitinationactivitybutincreasesactivitytowardp53.Mdm2alsoaffectsthecellcycleandCancerthroughinteractionswithotherproteinssuchasretinoblastoma1(pRB)andribosomalproteinL5.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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